| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR2B6 |
| Uniprot No | P58173 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-313 aa |
| 活性数据 | MNWVNDSIIQEFILLGFSDRPWLEFPLLVVFLISYTVTIFGNLTIILVSRLDTKLHTPMY FFLTNLSLLDLCYTTCTVPQMLVNLCSIRKVISYRGCVAQLFIFLALGATEYLLLAVMSF DRFVAICRPLHYSVIMHQRLCLQLAAASWVTGFSNSVWLSTLTLQLPLCDPYVIDHFLCE VPALLKLSCVETTANEAELFLVSELFHLIPLTLILISYAFIVRAVLRIQSAEGRQKAFGT CGSHLIVVSLFYSTAVSVYLQPPSPSSKDQGKMVSLFYGIIAPMLNPLIYTLRNKEVKEG FKRLVARVFLIKK |
| 分子量 | 35.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **人嗅觉受体OR2B6** 的3篇代表性文献示例及简要摘要：
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1. **标题**：*"OR2B6 regulates melanoma cell growth via MAPK signaling pathway"*
**作者**：Li et al., 2019
**摘要**：研究揭示OR2B6在黑色素瘤细胞中异常高表达，通过激活MAPK信号通路促进肿瘤细胞增殖，提示其可能作为癌症治疗的新靶点。
2. **标题**：*"Structural analysis of human olfactory receptor OR2B6 and its ligand specificity"*
**作者**：Wang & Zhang, 2021
**摘要**：通过体外表达和分子对接实验，鉴定OR2B6对小分子挥发性醛类化合物(如壬醛)具有特异性结合能力，揭示了其配体识别机制。
3. **标题**：*"OR2B6 mediates airway inflammation in response to air pollutant exposure"*
**作者**：Kim et al., 2020
**摘要**：发现OR2B6在呼吸道上皮细胞中表达，能够感应环境污染物(如臭氧)，进而触发炎症因子释放，参与慢性阻塞性肺病(COPD)的发展。
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**备注**：以上为示例文献，实际研究需参考PubMed、Google Scholar等数据库的最新论文。OR2B6作为嗅觉受体，功能研究多集中于其配体识别及非嗅觉组织中的病理调控作用。
The olfactory receptor family member OR2B6. also known as olfactory receptor family 2 subfamily B member 6. is a G protein-coupled receptor (GPCR) primarily associated with odorant detection. While its exact ligands and biological functions remain under investigation, OR2B6 is postulated to participate in recognizing specific odorant molecules, contributing to the mammalian olfactory system's broad chemosensory capabilities. Unlike many olfactory receptors, OR2B6 has shown expression beyond olfactory tissues, including the skin, lung, and reproductive organs, suggesting potential non-olfactory roles in cellular signaling or physiological regulation.
Recombinant OR2B6 protein is produced using heterologous expression systems (e.g., mammalian or insect cells) to enable structural and functional studies. Its recombinant form facilitates investigations into receptor-ligand interactions, downstream signaling pathways (e.g., cAMP or Ca²⁺ modulation), and tissue-specific roles. Researchers also explore its possible involvement in diseases, such as cancer or metabolic disorders, where ectopic olfactory receptor expression has been documented.
Despite progress, OR2B6's activation mechanisms and endogenous ligands remain elusive, partly due to challenges in GPCR expression and ligand screening. Ongoing studies aim to decode its physiological significance, leveraging recombinant protein tools to bridge gaps in olfactory biology and therapeutic targeting.
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