| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR56B1 |
| Uniprot No | Q8NGI3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-324 aa |
| 活性数据 | MNHMSASLKISNSSKFQVSEFILLGFPGIHSWQHWLSLPLALLYLSALAANTLILIIIWQ NPSLQQPMYIFLGILCMVDMGLATTIIPKILAIFWFDAKVISLPECFAQIYAIHFFVGME SGILLCMAFDRYVAICHPLRYPSIVTSSLILKATLFMVLRNGLFVTPVPVLAAQRDYCSK NEIEHCLCSNLGVTSLACDDRRPNSICQLVLAWLGMGSDLSLIILSYILILYSVLRLNSA EAAAKALSTCSSHLTLILFFYTIVVVISVTHLTEMKATLIPVLLNVLHNIIPPSLNPTVY ALQTKELRAAFQKVLFALTKEIRS |
| 分子量 | 36.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于OR56B1蛋白的3篇参考文献简述，基于现有研究背景模拟整理：
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1. **文献名称**: *Olfactory receptor OR56B1 is a coreceptor for the detection of the floral odorant β-ionone in humans*
**作者**: Smith A, et al.
**摘要**：研究表明OR56B1是一种嗅觉受体，特异性识别挥发性化合物β-紫罗兰酮，揭示了其在嗅觉感知中的配体结合机制及信号转导途径。
2. **文献名称**: *Ectopic expression of olfactory receptor OR56B1 in non-olfactory tissues and its potential role in inflammation*
**作者**: Chen L, Wang H.
**摘要**：发现OR56B1在肠道、肺等非嗅觉组织中表达，可能与炎症反应调节相关，推测其通过识别微生物代谢产物参与免疫调控。
3. **文献名称**: *Genetic variation in OR56B1 and its association with dietary preferences in human populations*
**作者**: Garcia R, et al.
**摘要**：通过基因组关联分析，发现OR56B1基因多态性与个体对特定食物(如坚果类)的气味感知差异相关，暗示其影响饮食行为选择。
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注：以上文献为模拟示例，实际研究中需根据真实数据库(如PubMed)检索具体文献。若需进一步查阅，建议使用关键词“OR56B1”或“olfactory receptor 56B1”在学术平台进行精准搜索。
Recombinant human OR56B1 protein is a genetically engineered form of the olfactory receptor 56B1. a class A G protein-coupled receptor (GPCR) traditionally associated with odorant detection in the olfactory epithelium. While olfactory receptors are predominantly expressed in nasal tissues, OR56B1 has gained attention due to its ectopic expression in non-chemosensory tissues, including the prostate, testes, and brain, suggesting potential non-canonical physiological roles. This receptor belongs to the pH-sensitive subfamily of olfactory receptors, with proposed activation mechanisms potentially linked to extracellular pH changes rather than specific odorant molecules, though its endogenous ligands remain unidentified.
The recombinant protein is typically produced in heterologous systems like E. coli or mammalian cells, enabling structural and functional studies that are challenging in native tissues. Its production has facilitated investigations into receptor-ligand interactions, signaling pathways, and tissue-specific splice variants. Structurally, OR56B1 features seven transmembrane domains characteristic of GPCRs, with an extracellular N-terminal domain containing potential glycosylation sites and intracellular loops mediating G-protein coupling.
Emerging research implicates OR56B1 in pathological processes, including cancer cell proliferation and metabolic dysregulation. Its ectopic expression in prostate cancer models has been correlated with disease progression, while neuronal expression patterns suggest potential involvement in neurodegenerative conditions. The recombinant protein serves as a critical tool for developing high-throughput screening platforms to identify modulators targeting pH-sensitive signaling mechanisms. As part of the druggable GPCR superfamily, OR56B1 represents a promising candidate for therapeutic intervention, particularly in pH-associated pathologies and chemosensory-mimetic drug development.
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