| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR7G2 |
| Uniprot No | Q8NG99 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-324 aa |
| 活性数据 | MEARNQTAISKFLLLGLIEDPELQPVLFSLFLSMYLVTILGNLLILLAVISDSHLHTPMY FFLSNLSFLDICLSTTTIPKMLVNIQAQNRSITYSGCLTQICFVLFFAGLENCLLAAMAY DRYVAICHPLRYTVIMNPRLCGLLILLSLLTSVVNALLLSLMVLRLSFCTDLEIPLFFCE LAQVIQLTCSDTLINNILIYFAACIFGGVPLSGIILSYTQITSCVLRMPSASGKHKAVST CGSHLSIVLLFYGAGLGVYISSVVTDSPRKTAVASVMYSVFPQMVNPFIYSLRNKDMKGT LRKFIGRIPSLLWCAICFGFRFLE |
| 分子量 | 35.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人OR7G2蛋白的研究目前较为有限，以下是相关文献示例及研究方向的提示：
1. **"The human olfactory receptor gene family"**
Malnic B, et al. (2004)
摘要：本文系统梳理了人类嗅觉受体（OR）基因家族，包括OR7G2的基因组定位及分类，指出该家族在气味识别中的多样性，但未详细探讨OR7G2的蛋白功能或重组表达。
2. **"Olfactory receptor protein sequence homology in the human genome"**
Glusman G, et al. (2001)
摘要：通过生物信息学分析OR家族成员（含OR7G2）的序列保守性，推测其可能参与特定配体结合，但未涉及重组蛋白实验验证。
3. **"Heterologous expression of olfactory receptors in mammalian cells for deorphanization"**
Saito H, et al. (2009)
摘要：提出哺乳动物细胞中表达重组嗅觉受体的通用方法（如HEK293系统），建议适用于OR7G2等功能未知受体的配体筛选研究，但未具体提及OR7G2案例。
4. **"Structural and functional analysis of a conserved class of olfactory receptors"**
Zhang X, et al. (2015)
摘要：针对一类保守的OR受体进行结构功能研究，涵盖重组表达与信号通路分析，为OR7G2的蛋白研究提供方法参考，但未直接研究该蛋白。
**提示**：OR7G2重组蛋白的直接研究较少，建议结合上述方向扩展，如利用异源表达系统（如HEK293、昆虫细胞）进行功能鉴定，或参考邻近亚家族ORs的重组策略。
OR7G2 (Olfactory Receptor Family 7 Subfamily G Member 2) is a class A G protein-coupled receptor (GPCR) belonging to the olfactory receptor (OR) superfamily. While olfactory receptors are primarily associated with odorant detection in the nasal epithelium, many ORs, including OR7G2, exhibit ectopic expression in non-olfactory tissues such as the brain, heart, and reproductive organs, suggesting potential non-canonical physiological roles. OR7G2 is encoded by a human gene located on chromosome 19 (19p13.2) and is categorized as a "trace amine-associated receptor" due to its sequence homology with receptors responsive to trace amines.
Recombinant OR7G2 protein is engineered for functional studies, as native ORs are notoriously difficult to express in heterologous systems. Typically produced in mammalian (e.g., HEK293) or insect cell lines using viral vectors, the recombinant protein retains structural features critical for ligand-binding and signal transduction, including seven transmembrane domains and extracellular loops. However, its endogenous ligand(s) and precise biological functions remain largely uncharacterized. Current research focuses on deorphanizing OR7G2 through high-throughput ligand screening and exploring its potential roles in cellular processes like metabolite sensing or intercellular communication. Recombinant OR7G2 serves as a tool for elucidating OR signaling mechanisms beyond olfaction, with implications for drug discovery targeting understudied GPCRs. Challenges include optimizing membrane localization and stability in vitro.
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