| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ORAOV1 |
| Uniprot No | Q8WV07 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-137 aa |
| 活性数据 | AGSQDIFDA IVMADERFHG EGYREGYEEG SSLGVMEGRQ HGTLHGAKIG SEIGCYQGFA FAWKCLLHSC TTEKDSRKMK VLESLIGMIQ KFPYDDPTYD KLHEDLDKIR GKFKQFCSLL NVQPDFKISA EGSGLSF |
| 分子量 | 15.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ORAOV1蛋白的文献示例（内容为模拟，仅供参考）：
1. **文献名称**：ORAOV1 promotes tumor proliferation via interaction with AKT signaling in esophageal squamous cell carcinoma
**作者**：Li X. et al.
**摘要**：研究探讨了重组ORAOV1蛋白在食管癌细胞中的促增殖作用，发现其通过激活AKT通路增强肿瘤细胞存活能力。
2. **文献名称**：Recombinant ORAOV1 enhances cisplatin resistance by regulating mitochondrial apoptosis pathways in oral cancer
**作者**：Wang Y. et al.
**摘要**：利用重组ORAOV1蛋白实验，证明其通过抑制线粒体凋亡通路导致口腔癌细胞对顺铂产生耐药性。
3. **文献名称**：Structural characterization and functional analysis of recombinant ORAOV1 protein in hepatocellular carcinoma
**作者**：Zhang R. et al.
**摘要**：纯化并解析了重组ORAOV1蛋白的结构，发现其通过结合β-catenin促进肝癌细胞侵袭转移。
4. **文献名称**：ORAOV1 as a potential biomarker: Expression profiling of recombinant protein in gastric cancer tissues
**作者**：Chen H. et al.
**摘要**：通过免疫组化分析重组ORAOV1蛋白在胃癌中的高表达，提示其与患者预后不良相关。
**注意**：以上为基于文献模式的模拟内容，实际文献需通过PubMed、Google Scholar等平台检索关键词“recombinant ORAOV1 protein”或“ORAOV1 oncogene”获取。
The ORAOV1 (Oral Cancer Overexpressed 1) protein, encoded by the ORAOV1 gene located on chromosome 11q13, has garnered attention due to its frequent amplification in various cancers, particularly oral squamous cell carcinoma. This gene resides within the 11q13 locus, a chromosomal region often amplified in malignancies, correlating with poor prognosis. ORAOV1 is a conserved single-pass transmembrane protein, though its exact structural domains remain understudied. Functionally, it is implicated in promoting tumorigenesis, potentially through interactions with metabolic pathways or signaling cascades. While its precise mechanisms remain unclear, studies suggest roles in cell proliferation, survival, and metabolic reprogramming, possibly via modulating reactive oxygen species (ROS) or autophagy. Notably, ORAOV1 overexpression is linked to therapeutic resistance in cancers like esophageal and breast cancer. Despite being initially identified as overexpressed in oral cancers, its expression patterns and oncogenic contributions appear context-dependent across tumor types. Current research focuses on elucidating its molecular interactions, validating its potential as a diagnostic or prognostic biomarker, and exploring its therapeutic targeting. However, functional redundancy and undefined downstream effectors remain challenges. Further investigations are needed to unravel its precise pathological roles and exploit its clinical relevance in precision oncology.
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