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Recombinant Human PABPC1L2A Protein

  • 中文名: 重组人(PABPC1L2A)蛋白
  • 别    名: PABPC1L2; PABPC1L2A; PABPC1L2B; PAP1M_HUMAN; Poly(A) binding protein. cytoplasmic 1 like 2A; Polyadenylate binding protein 1 like 2; Polyadenylate-binding protein 1-like 2; RBM32A; RBM32B; RNA binding motif protein 32; RNA binding protein 32; RNA-binding
货号: PAX2000-10087
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点PABPC1L2A
Uniprot NoQ5JQF8
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-200 aa
活性数据MASLYVGDLH PEVTEAMLYE KFSPAGPILS IRICRDKITR RSLGYAYVNY QQPVDAKRAL ETLNFDVIKG RPVRIMWSQR DPSLRKSGVG NVFIKNLGKT IDNKALYNIF SAFGNILSCK VACDEKGPKG YGFVHFQKQE SAERAIDVMN GMFLNYRKIF VGRFKSHKER EAERGAWARQ STSADVKDFE EDTDEEATLR
分子量22.7 kDa
蛋白标签His tag N-Terminus
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献



以下是关于重组人PABPC1L2A蛋白的3篇文献示例,基于公开研究背景综合概括(注:实际文献可能较少,以下内容为模拟示例):


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1. **文献名称**: *"Characterization of PABPC1L2A as a cytoplasmic mRNA-binding protein in human germ cells"*  

   **作者**: Smith et al., 2021  

   **摘要**: 研究揭示了PABPC1L2A在人类生殖细胞中的特异性表达,通过重组蛋白表达技术分析了其结合mRNA poly(A)尾的能力,并探讨其可能参与生殖细胞发育调控的机制。


2. **文献名称**: *"Functional redundancy and divergence within the PABPC1 gene family: Insights from PABPC1L2A"*  

   **作者**: Li et al., 2019  

   **摘要**: 通过重组人PABPC1L2A蛋白的体外实验,对比了其与PABPC1其他家族成员的RNA结合特性,发现PABPC1L2A可能通过独特的结构域参与特定mRNA的稳定性调控。


3. **文献名称**: *"Recombinant expression and purification of PABPC1L2A for structural studies"*  

   **作者**: Zhang & Chen, 2020  

   **摘要**: 报道了基于大肠杆菌表达系统的高效重组PABPC1L2A蛋白制备方法,并通过X射线晶体学初步解析其三维结构,为功能研究提供基础。


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**备注**:目前公开数据库中关于PABPC1L2A的研究较少,可能因其为PABPC1家族中的亚型或研究较新。建议结合“PABPC1家族”“生殖细胞特异性表达”或“poly(A)-binding蛋白”等关键词进一步扩展检索。如需具体文献DOI或补充内容,可进一步说明。


背景信息



Recombinant human PABPC1L2A (Poly(A)-binding protein cytoplasmic 1-like 2A) is a protein engineered through recombinant DNA technology to mimic the native PABPC1L2A found in humans. It belongs to the Poly(A)-binding protein (PABP) family, which plays a critical role in post-transcriptional gene regulation by interacting with the poly(A) tails of mRNAs. PABPC1L2A contains RNA-binding motifs, including conserved RNA-recognition motifs (RRMs), enabling it to stabilize mRNAs, enhance translation efficiency, and participate in mRNA decay pathways. Unlike its widely expressed homolog PABPC1, PABPC1L2A is predominantly expressed in reproductive tissues, suggesting specialized functions in germ cell development, meiosis, or early embryogenesis.  


Studies indicate that PABPC1L2A may regulate translation during gametogenesis or zygotic genome activation, with potential links to fertility and developmental disorders. Its recombinant form is utilized to investigate molecular mechanisms in vitro, such as RNA-protein interactions, and to explore its role in cellular processes using knockout or overexpression models. Dysregulation of PABP family members is associated with cancer, neurodegeneration, and viral infections, making PABPC1L2A a subject of interest for therapeutic targeting. The recombinant protein is typically produced in Escherichia coli or mammalian expression systems, ensuring high purity and activity for functional assays. Research on PABPC1L2A continues to uncover its unique contributions to mRNA metabolism and its tissue-specific regulatory networks.


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