| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PRRX2 |
| Uniprot No | Q99811 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-253 aa |
| 活性数据 | MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA AAGRLAARPG ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR KKKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREELARR VNLSEARVQV WFQNRRAKFR RNERAMLASR SASLLKSYSQ EAAIEQPVAP RPTALSPDYL SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK EFSLHHSQVP TVN |
| 分子量 | 27.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于PRRX2蛋白的3篇参考文献摘要(基于公开研究内容归纳，部分为模拟示例)：
1. **"PRRX2 regulates craniofacial development through epithelial-mesenchymal transition"**
- **作者**: Smith A, et al.
- **摘要**: 研究揭示PRRX2通过调控EMT相关基因(如SNAI1)参与小鼠颅面发育，PRRX2缺失导致神经嵴细胞迁移异常及腭裂表型，提示其在胚胎形态发生中的关键作用。
2. **"PRRX2 suppresses tumor metastasis by antagonizing TGF-β signaling in breast cancer"**
- **作者**: Chen L, et al.
- **摘要**: 发现PRRX2在乳腺癌中作为抑癌因子，通过抑制TGF-β/Smad通路降低癌细胞侵袭能力，高表达PRRX2患者预后较好，提示其临床治疗潜力。
3. **"Comparative analysis of PRRX1 and PRRX2 in skeletal muscle regeneration"**
- **作者**: Tanaka R, et al.
- **摘要**: 对比PRRX1/PRRX2在肌肉干细胞中的功能差异，发现PRRX2特异性促进成肌细胞分化，而PRRX1主导干细胞静止态维持，揭示了二者在组织再生中的互补作用。
注：以上文献为模拟示例，实际研究需通过PubMed/Google Scholar以"PRRX2"为关键词检索最新文献。
PRRX2 (Paired Related Homeobox 2) is a member of the PRRX family of homeodomain-containing transcription factors, which play crucial roles in developmental processes. Structurally, it features a conserved homeodomain responsible for DNA binding and additional domains that mediate protein-protein interactions, enabling transcriptional regulation. PRRX2 is closely related to PRRX1. with both sharing overlapping roles in embryogenesis, particularly in skeletal development, organogenesis, and craniofacial patterning. Studies highlight its involvement in cell differentiation, migration, and tissue remodeling during development.
In adults, PRRX2 expression persists in certain tissues, including mesenchymal stem cells and neural systems, suggesting roles in tissue homeostasis and regeneration. Emerging evidence links PRRX2 to neural development and function, such as axon guidance and neurotransmitter regulation. Its dysregulation has been implicated in neurological disorders and cancers, though its mechanisms remain less studied compared to PRRX1. For instance, PRRX2 may act as a tumor suppressor or promoter depending on context, with studies showing contradictory roles in metastasis and epithelial-mesenchymal transition (EMT).
Research on PRRX2 is still evolving, focusing on its regulatory networks, interaction partners, and potential therapeutic applications in regenerative medicine or disease modulation. Its dual role in development and pathology underscores its biological complexity and therapeutic relevance.
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