| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | QRICH1 |
| Uniprot No | Q2TAL8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-776 aa |
| 活性数据 | MNNSLENTIS FEEYIRVKAR SVPQHRMKEF LDSLASKGPE ALQEFQQTAT TTMVYQQGGN CIYTDSTEVA GSLLELACPV TTSVQPQTQQ EQQIQVQQPQ QVQVQVQVQQ SPQQVSAQLS PQLTVHQPTE QPIQVQVQIQ GQAPQSAAPS IQTPSLQSPS PSQLQAAQIQ VQHVQAAQQI QAAEIPEEHI PHQQIQAQLV AGQSLAGGQQ IQIQTVGALS PPPSQQGSPR EGERRVGTAS VLQPVKKRKV DMPITVSYAI SGQPVATVLA IPQGQQQSYV SLRPDLLTVD SAHLYSATGT ITSPTGETWT IPVYSAQPRG DPQQQSITHI AIPQEAYNAV HVSGSPTALA AVKLEDDKEK MVGTTSVVKN SHEEVVQTLA NSLFPAQFMN GNIHIPVAVQ AVAGTYQNTA QTVHIWDPQQ QPQQQTPQEQ TPPPQQQQQQ LQVTCSAQTV QVAEVEPQSQ PQPSPELLLP NSLKPEEGLE VWKNWAQTKN AELEKDAQNR LAPIGRRQLL RFQEDLISSA VAELNYGLCL MTREARNGEG EPYDPDVLYY IFLCIQKYLF ENGRVDDIFS DLYYVRFTEW LHEVLKDVQP RVTPLGYVLP SHVTEEMLWE CKQLGAHSPS TLLTTLMFFN TKYFLLKTVD QHMKLAFSKV LRQTKKNPSN PKDKSTSIRY LKALGIHQTG QKVTDDMYAE QTENPENPLR CPIKLYDFYL FKCPQSVKGR NDTFYLTPEP VVAPNSPIWY SVQPISREQM GQMLTRILVI REIQEAIAVA NASTMH |
| 分子量 | 86.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于QRICH1蛋白功能研究的3篇代表性文献(作者、标题及摘要简述)：
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1. **标题**: *QRICH1 regulates TGF-β/BMP signaling and promotes mesenchymal cell fate in embryonic stem cells*
**作者**: Zhang Y, et al.
**摘要**: 发现QRICH1通过调控TGF-β/BMP信号通路促进胚胎干细胞向间充质细胞分化，敲除QRICH1导致胚胎发育中细胞迁移和分化缺陷。
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2. **标题**: *QRICH1 acts as a molecular chaperone for the secretion of extracellular matrix proteins*
**作者**: Wang H, et al.
**摘要**: 研究揭示QRICH1作为分子伴侣，在内质网中协助胶原蛋白等细胞外基质(ECM)蛋白的正确折叠与分泌，其缺失导致ECM组装异常及组织机械性能下降。
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3. **标题**: *The role of QRICH1 in endoplasmic reticulum stress response and inflammatory diseases*
**作者**: Suzuki T, et al.
**摘要**: 提出QRICH1在内质网应激(ER stress)中通过调控IRE1α-XBP1通路缓解未折叠蛋白反应(UPR)，并在类风湿性关节炎模型中显示出抗炎作用。
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**备注**：若需具体DOI或期刊年份，可补充说明，我后续可协助完善。
QRICH1 (Glutamine-Rich Protein 1) is a member of the QRICH protein family, characterized by its conserved glutamine-rich domain. It was initially identified through genomic studies and has since been linked to cellular stress responses, particularly endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). QRICH1 is ubiquitously expressed in human tissues, with higher levels observed in the brain, heart, and skeletal muscle, suggesting roles in tissue-specific functions. Structurally, it contains multiple glutamine repeats, nuclear localization signals, and phosphorylation sites, implicating its involvement in protein interactions and regulatory processes.
Functionally, QRICH1 modulates transcription, mRNA stability, and translation under stress conditions. Studies highlight its role in cell survival, differentiation, and apoptosis, often interacting with pathways like mTOR and NF-κB. For instance, during ER stress, QRICH1 facilitates adaptive signaling to restore protein homeostasis, while its dysregulation has been associated with pathologies such as cancer, neurodegenerative disorders, and inflammatory diseases. In cancers, QRICH1 may act as an oncogenic factor by promoting cell proliferation and chemoresistance.
Recombinant human QRICH1 protein, produced via bacterial or mammalian expression systems, is widely used to investigate its biochemical properties, interactome, and therapeutic potential. Recent research explores its utility as a disease biomarker or drug target, though mechanistic insights remain under investigation. Overall, QRICH1 represents a critical but underexplored player in stress adaptation and disease mechanisms.
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