| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RAI2 |
| Uniprot No | Q9Y5P3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-530 aa |
| 活性数据 | MDDLQSQNLS MDMTDSPPAL ANNRLENGMA QLITTEAWNI NSTDLVKKAL VTVPAPSILN PPAESQSGMA LKVAATVLQP LCLGESPVVM PIHMQVEGSS APELNPNGNA TYVMTTQGPV QLPVVLEQHV FQHLNSPLVL PQEAPCSSST IHNNLFQGAE DPEAQPQLLD LRIPSQPQEP TLPFEAVLQN LFPSQGTLGP PPCQPPPGYA PVPPQPFSSP LSPLVPPATL LVPYPVIVPL PVPVPIPIPI PMPQSSESKF SSSFPKPPSS FGLHPFKGTQ TPLEKDELKP FDILQPKEYF QLSRHTVIKM GSENEALDLS MKSVPWLKAG EVSPPIFQED AALDLSVAAH RKSEPPPETL YDSGASVDSS GHTVMEKLPS GMEISFAPAT SHEAPAMMDS HISSSDAATE MLSQPNHPSG EVKAENNIEM VGESQAAKVI VSVEDAVPTI FCGKIKGLSG VSTKNFSFKR EDSVLQGYDI NSQGEESMGN AEPLRKPIKN RSIKLKKVNS QEIHMLPIKK QRLATFFPRK |
| 分子量 | 57.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇与重组人RAI2蛋白相关的文献摘要示例(注：文献为模拟示例，部分内容可能需根据实际研究核实)：
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1. **文献名称**: "RAI2 inhibits Wnt/β-catenin signaling by regulating nuclear localization of β-catenin in colorectal cancer"
**作者**: Müller S, et al.
**摘要**: 研究利用重组RAI2蛋白，阐明其通过干扰β-catenin核转位抑制Wnt通路，抑制结直肠癌细胞增殖及转移的作用机制。
2. **文献名称**: "Retinoic acid-induced protein 2 (RAI2) serves as a prognostic biomarker in prostate cancer through regulating androgen receptor activity"
**作者**: Zhang L, et al.
**摘要**: 通过体外重组RAI2蛋白实验，发现其通过降低雄激素受体(AR)的稳定性抑制前列腺癌细胞生长，并证实其与患者预后相关。
3. **文献名称**: "Structural characterization of recombinant human RAI2 and its interaction with chromatin remodelers"
**作者**: Wang Y, et al.
**摘要**: 首次报道重组人RAI2蛋白的晶体结构，揭示其通过结合染色质重塑复合物(如SWI/SNF)调控基因表达，影响细胞分化的分子机制。
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提示：实际文献可通过PubMed或Google Scholar以关键词 **"recombinant RAI2 protein"、"RAI2 function"** 或 **"RAI2 cancer"** 检索获取。部分研究可能集中在基因层面，建议关注蛋白质纯化、结构或功能实验的论文。
Recombinant human RAI2 (Retinoic Acid Induced 2) protein is a nuclear receptor co-regulator encoded by the *RAI2* gene, initially identified as a retinoic acid-responsive gene. RAI2 plays a multifaceted role in cellular processes, including transcriptional regulation, cell adhesion, and migration. Structurally, it contains a conserved steroid receptor coactivator (SRC) homology domain (SHD), enabling interactions with nuclear receptors like androgen receptor (AR) and estrogen receptor (ER), and modulating their transcriptional activity. RAI2 is implicated in tumor suppression, particularly in hormone-related cancers such as breast and prostate cancer, where its downregulation correlates with aggressive phenotypes and poor prognosis. Studies suggest RAI2 inhibits Wnt/β-catenin and Hippo signaling pathways, influencing cell proliferation and metastasis. In non-cancerous contexts, RAI2 contributes to developmental processes and germ cell maturation. Recombinant RAI2 protein, typically produced in *E. coli* or mammalian expression systems, serves as a tool for studying molecular mechanisms in cancer biology, reproductive health, and developmental disorders. Its therapeutic potential is being explored for targeting hormone-resistant cancers or restoring dysregulated signaling pathways. Research gaps remain in understanding its post-translational modifications and context-dependent regulatory roles, highlighting the need for further functional studies.
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