| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL17RE |
| Uniprot No | Q8NFR9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-667aa |
| 氨基酸序列 | MGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCIEASYLQEDTVRRKKCPFQSWPEAYGSDFWKSVHFTDYSQHTQMVMALTLRCPLKLEAALCQRHDWHTLCKDLPNATARESDGWYVLEKVDLHPQLCFKFSFGNSSHVECPHQTGSLTSWNVSMDTQAQQLILHFSSRMHATFSAAWSLPGLGQDTLVPPVYTVSQARGSSPVSLDLIIPFLRPGCCVLVWRSDVQFAWKHLLCPDVSYRHLGLLILALLALLTLLGVVLALTCRRPQSGPGPARPVLLLHAADSEAQRRLVGALAELLRAALGGGRDVIVDLWEGRHVARVGPLPWLWAARTRVAREQGTVLLLWSGADLRPVSGPDPRAAPLLALLHAAPRPLLLLAYFSRLCAKGDIPPPLRALPRYRLLRDLPRLLRALDARPFAEATSWGRLGARQRRQSRLELCSRLEREAARLADLG |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL17RE重组蛋白的3篇代表性文献摘要(注：文献为虚拟示例，实际研究需根据具体数据库检索)：
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1. **文献名称**: *"Functional characterization of recombinant IL17RE in IL-17A/F-mediated inflammatory responses"*
**作者**: Tanaka K, et al.
**摘要**: 研究通过昆虫细胞系统表达并纯化IL17RE重组蛋白，证实其与IL-17A/F结合后激活NF-κB信号通路，促进炎症因子释放，揭示了其在自身免疫疾病中的潜在调控机制。
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2. **文献名称**: *"Recombinant IL17RE extracellular domain inhibits psoriasis-like inflammation in murine models"*
**作者**: Chen L, et al.
**摘要**: 利用哺乳动物细胞表达IL17RE胞外段重组蛋白，证明其通过竞争性结合IL-17配体阻断下游信号，显著减轻小鼠银屑病模型的皮肤炎症，提示其作为治疗靶点的潜力。
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3. **文献名称**: *"Structural insights into IL17RE activation via recombinant protein crystallography"*
**作者**: Müller S, et al.
**摘要**: 通过重组IL17RE蛋白的晶体结构解析，发现其与IL-17F的相互作用界面关键氨基酸残基，为设计靶向IL17RE的小分子抑制剂提供了结构基础。
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如需真实文献，建议在PubMed或Sci-Hub中以“IL17RE recombinant protein”为关键词检索，并筛选近5年高被引论文。
**Background of IL-17RE Recombinant Protein**
Interleukin-17 receptor E (IL-17RE) is a member of the IL-17 receptor (IL-17R) family, which plays a critical role in mediating inflammatory and immune responses. As a Type I transmembrane protein, IL-17RE is primarily expressed in epithelial and immune cells. It functions as a co-receptor for IL-17A and IL-17F, cytokines involved in host defense and pathogenesis of autoimmune diseases. IL-17RE forms heterodimeric complexes with IL-17RA, facilitating downstream signaling through NF-κB and MAPK pathways, which regulate pro-inflammatory gene expression.
The recombinant IL-17RE protein is engineered to study its structural and functional properties in vitro. Produced via mammalian expression systems (e.g., HEK293 or CHO cells), it retains post-translational modifications essential for ligand binding and signaling. The purified protein typically includes a fusion tag (e.g., Fc or His-tag) for enhanced stability and ease of detection in assays.
Research on IL-17RE has highlighted its dual role in immunity: it promotes antimicrobial defense but also contributes to chronic inflammation in conditions like psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Dysregulation of IL-17RE signaling is further implicated in cancer progression, particularly in tumor microenvironments.
Recombinant IL-17RE is widely used in ligand-receptor interaction studies, inhibitor screening, and structural biology to develop targeted therapies. Its production under stringent quality control (e.g., SDS-PAGE, ELISA) ensures high purity and bioactivity, making it a vital tool for dissecting IL-17 pathway mechanisms and therapeutic intervention strategies.
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