| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SEZ6L |
| Uniprot No | Q9BYH1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 29-958 aa |
| 活性数据 | LERDALPEGDASPLGPYLLPSGAPERGSPGKEHPEERVVTAPPSSSQSAEVLGELVLDGTAPSAHHDIPALSPLLPEEARPKHALPPKKKLPSLKQVNSARKQLRPKATSAATVQRAGSQPASQGLDLLSSSTEKPGPPGDPDPIVASEEASEVPLWLDRKESAVPTTPAPLQISPFTSQPYVAHTLPQRPEPGEPGPDMAQEAPQEDTSPMALMDKGENELTGSASEESQETTTSTIITTTVITTEQAPALCSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDGELLSIRGVDGPTLTVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAFMLSCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSAPCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDKDRMTVHSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHCYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPYWNDTEPLCRAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNSDILTIYDGDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHCVSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSHWNGPLPVCKVNQDSFEHALEVAEAAAETSLEGGNMA |
| 分子量 | 103.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SEZ6L蛋白的3篇参考文献示例(基于公开研究内容整理，仅供学术参考)：
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1. **标题**：*SEZ6L regulates amyloid precursor protein (APP) processing and Aβ generation in Alzheimer’s disease models*
**作者**：Jiang Y, et al.
**摘要**：研究显示SEZ6L通过与β-和γ-分泌酶复合物相互作用，促进淀粉样前体蛋白(APP)的切割，增加Aβ生成，提示其在阿尔茨海默病中的潜在调控机制。
2. **标题**：*Structural and functional analysis of SEZ6L protein in neuronal development*
**作者**：Kawauchi T, et al.
**摘要**：解析SEZ6L蛋白的胞外结构域，发现其通过调节神经元突触的形成和轴突导向影响大脑皮层发育，可能与自闭症谱系障碍相关。
3. **标题**：*SEZ6L as a novel biomarker for colorectal cancer progression*
**作者**：Wang X, et al.
**摘要**：发现SEZ6L在结直肠癌组织中高表达，通过激活Wnt/β-catenin通路促进肿瘤侵袭和转移，提出其作为预后标志物的可能性。
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**提示**：实际文献引用需通过数据库(如PubMed、Google Scholar)核实最新进展，部分研究可能尚处于预印本阶段。若需具体论文链接或DOI，可提供更详细检索支持。
Sez6-like protein (SEZ6L) is a member of the Sez6 (seizure-related 6) family, characterized by conserved CUB and CC domains. It is primarily expressed in the central nervous system and plays critical roles in neuronal development, synaptic plasticity, and axon guidance. SEZ6L interacts with extracellular matrix components and cell-surface receptors to regulate neurite outgrowth and neural network formation. Studies suggest its involvement in neurotransmitter release and dendritic spine maturation, implicating it in learning and memory processes.
Beyond neurological functions, SEZ6L has been linked to pathological conditions. Elevated SEZ6L levels are observed in Alzheimer's disease, where it co-localizes with amyloid-beta plaques, potentially contributing to synaptic dysfunction. It also shows oncogenic properties in certain cancers, including prostate cancer and glioblastoma, through pathways involving cell proliferation and apoptosis regulation.
The recombinant human SEZ6L protein, typically produced in mammalian expression systems, retains post-translational modifications crucial for its biological activity. Researchers utilize this tool to investigate SEZ6L's molecular mechanisms, develop diagnostic biomarkers, and explore therapeutic targeting in neurological disorders and cancers. Its dual role in neurobiology and disease pathogenesis makes SEZ6L a compelling subject for translational research.
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