| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SHCBP1 |
| Uniprot No | Q8NEM2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-672 aa |
| 活性数据 | ADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK WNGKGSFGTF LF |
| 分子量 | 75.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3-4条关于SHCBP1蛋白的参考文献示例(内容基于公开研究总结，非真实文献引用)：
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1. **标题**: *SHCBP1 promotes tumor cell cycle progression by stabilizing mitotic spindle assembly*
**作者**: Zhang, Y. et al.
**摘要**: 研究揭示SHCBP1通过调控纺锤体组装检查点(SAC)的稳定性，加速肿瘤细胞(如乳腺癌)的有丝分裂进程。SHCBP1缺失导致染色体分离错误并抑制肿瘤生长。
2. **标题**: *SHCBP1 interacts with EGFR signaling to enhance metastasis in gastric cancer*
**作者**: Liu, H. et al.
**摘要**: 发现SHCBP1与EGFR信号通路相互作用，促进胃癌细胞上皮间质转化(EMT)和转移，其高表达与患者预后不良显著相关。
3. **标题**: *SHCBP1 is a novel biomarker for neuroblastoma progression*
**作者**: Wang, J. et al.
**摘要**: 研究发现SHCBP1在神经母细胞瘤中异常高表达，通过激活PI3K/AKT通路驱动细胞周期进展，敲减后显著抑制肿瘤增殖并增强化疗敏感性。
4. **标题**: *Functional analysis of SHCBP1 in regulating SHC1 adaptor protein dynamics*
**作者**: Xu, L. et al.
**摘要**: 揭示SHCBP1通过调控SHC1蛋白的磷酸化和亚细胞定位，影响生长因子信号转导，可能在胚胎发育和肿瘤发生中发挥双重作用。
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*注：以上为模拟文献条目，实际研究需查阅PubMed、Google Scholar等平台获取真实引用。*
SHCBP1 (SHC SH2 Domain-Binding Protein 1) is a protein encoded by the SHCBP1 gene in humans. It is named for its interaction with the SH2 domain of SHC1. an adaptor protein involved in signal transduction pathways. SHCBP1 is primarily localized in the cytoplasm but has also been observed in the nucleus under certain conditions. Functionally, it is implicated in regulating cell proliferation, differentiation, and survival by modulating signaling pathways such as RAS/MAPK and PI3K/AKT, though its precise mechanisms remain under investigation.
Research highlights SHCBP1's role in cancer progression. Overexpression of SHCBP1 has been reported in various cancers, including breast, gastric, and hepatocellular carcinomas, where it promotes tumor growth, metastasis, and chemoresistance. It appears to influence cell cycle progression, apoptosis resistance, and epithelial-mesenchymal transition (EMT). Additionally, SHCBP1 is essential in reproductive system development. Studies in mice indicate that SHCBP1 deficiency disrupts meiosis during spermatogenesis, leading to infertility, suggesting its critical role in germ cell maturation.
Despite these findings, SHCBP1's full biological significance and regulatory networks are not yet fully understood. Its dual roles in oncogenesis and reproductive health make it a potential therapeutic target, warranting further exploration into its molecular interactions and pathophysiological contributions.
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