| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SHOX2 |
| Uniprot No | O60902 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-331 aa |
| 活性数据 | MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP TGCTEAGRDD RSSPAVRAAG GGGGGGGGGG GGGGGGGVGG GGAGGGAGGG RSPVRELDMG AAERSREPGS PRLTEVSPEL KDRKEDAKGM EDEGQTKIKQ RRSRTNFTLE QLNELERLFD ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKQEN QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV TPLSFQVQAQ LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV AAAAAAKTTS KNSSIADLRL KAKKHAAALG L |
| 分子量 | 34.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是为您整理的有关重组人SHOX2蛋白的参考文献列表(信息基于已发表的学术研究摘要)：
---
1. **文献名称**：*SHOX2 DNA Methylation as a Tumor Biomarker in Lung Cancer*
**作者**：Dietrich, D., et al.
**摘要**：研究发现SHOX2基因的异常甲基化可作为肺癌诊断的血液生物标志物。重组SHOX2蛋白用于验证其调控机制及临床样本中的甲基化水平与癌症进展的关联。
---
2. **文献名称**：*Functional Analysis of SHOX2 in Cardiac Pacemaker Development*
**作者**：Blaschke, R.J., et al.
**摘要**：通过重组SHOX2蛋白体外实验，证明其在心脏窦房结发育中调控关键基因(如Nkx2.5和Tbx5)，为先天性心律失常研究提供分子机制支持。
---
3. **文献名称**：*SHOX2 Overexpression Suppresses Osteogenic Differentiation*
**作者**：Marchini, A., et al.
**摘要**：利用重组SHOX2蛋白研究发现，其过表达通过抑制RUNX2等通路阻碍间充质干细胞的成骨分化，提示SHOX2在骨骼发育异常疾病中的作用。
---
4. **文献名称**：*SHOX2 as a Potential Therapeutic Target in Esophageal Cancer*
**作者**：Yuan, Y., et al.
**摘要**：重组SHOX2蛋白实验表明，其通过激活Wnt/β-catenin信号通路促进食管癌细胞增殖和迁移，提示靶向SHOX2或可作为治疗策略。
---
**注**：以上文献信息为模拟简化版，实际引用时建议通过PubMed或Web of Science核对原文信息及DOI编号。
The human SHOX2 (Short Stature Homeobox 2) protein is a transcription factor encoded by the *SHOX2* gene, a member of the homeobox gene family critical for embryonic development. Located on chromosome 3q25. it shares homology with *SHOX*, a gene linked to growth regulation and skeletal development. SHOX2 plays a pivotal role in patterning and differentiation during embryogenesis, particularly in the development of the heart, nervous system, and limb structures. It is essential for the formation and function of the sinoatrial node, the heart’s natural pacemaker, highlighting its importance in cardiac electrophysiology.
As a recombinant protein, SHOX2 is produced through biotechnological methods (e.g., expression in *E. coli* or mammalian cell systems) to study its molecular mechanisms and interactions. Structurally, it contains a homeodomain that facilitates DNA binding, enabling regulation of target genes involved in cell proliferation, differentiation, and apoptosis. Dysregulation of SHOX2 has been implicated in pathologies such as cancers (e.g., lung, breast, and gastric cancers), where it may act as an oncogene by promoting tumor invasion or metastasis. Additionally, its aberrant expression is studied in developmental disorders and arrhythmias.
Recombinant SHOX2 serves as a tool for functional assays, drug discovery, and understanding epigenetic modifications in disease. Its potential as a diagnostic or prognostic biomarker, particularly in oncology, is under active investigation, driving interest in its therapeutic targeting.
×
