| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLC37A3 |
| Uniprot No | Q8NCC5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-494 aa |
| 活性数据 | MAWPNVFQRGSLLSQFSHHHVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPVEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGLSGIEAEENFEEDSHRPLINGGENEDEYEPNYSIQDDSSVAQVKAISFYQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQYLVSLIRDKLGWMWVFYFFILMTSCTIVFISPLIVREIFSLVLRRQAHILRE |
| 分子量 | 80.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为模拟生成的3篇关于重组人SLC37A3蛋白的参考文献示例(实际文献需通过学术数据库验证)：
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1. **文献名称**: *Expression and Functional Characterization of Recombinant Human SLC37A3 in HEK293 Cells*
**作者**: Zhang Y. et al.
**摘要**: 本研究在HEK293细胞中成功表达了重组人SLC37A3蛋白，通过Western blot和免疫荧光确认其定位在内质网膜。功能实验表明SLC37A3具有葡萄糖-6磷酸转运活性，可能参与糖代谢调控。
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2. **文献名称**: *Structural Insights into SLC37A3 through Homology Modeling and Mutational Analysis*
**作者**: Lee S. et al.
**摘要**: 基于同源建模预测SLC37A3的跨膜结构域，并构建了重组蛋白突变体。生化实验发现关键氨基酸残基(如第158位组氨酸)对底物结合至关重要，为疾病相关突变研究提供基础。
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3. **文献名称**: *SLC37A3 Deficiency Alters Glycogen Storage in a Cellular Model*
**作者**: Martinez R. et al.
**摘要**: 利用重组SLC37A3敲低的肝细胞模型，发现该蛋白缺失导致糖原积累异常和自噬通路激活，提示其在糖代谢疾病中的潜在作用。
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**注意事项**：
- 以上文献为模拟示例，实际研究需通过PubMed、Google Scholar等平台检索关键词“SLC37A3 recombinant”或结合其已知功能(如磷酸盐转运体、糖代谢关联)查找。
- 真实研究中SLC37A3的文献可能较少，建议扩展检索其家族蛋白(如SLC37A4)或交叉引用相关综述。
The solute carrier family 37 member 3 (SLC37A3) is a transmembrane protein encoded by the *SLC37A3* gene located on human chromosome 7q11.23. Belonging to the SLC37 family, SLC37A3 shares structural homology with organophosphate:phosphate antiporters, featuring multiple transmembrane domains and conserved residues critical for substrate transport. While its exact physiological role remains under investigation, SLC37A3 is proposed to function as a sugar-phosphate exchanger, potentially regulating glucose metabolism and cellular energy homeostasis. It is predominantly expressed in the liver, kidney, and intestines, suggesting involvement in gluconeogenesis, glycogen synthesis, or nutrient sensing.
Recent studies link SLC37A3 to metabolic diseases. Notably, its dysregulation has been associated with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD), possibly through altered glucose-6-phosphate transport or endoplasmic reticulum stress modulation. In cancer, aberrant SLC37A3 expression correlates with tumor progression, though mechanisms are unclear. Recombinant human SLC37A3 protein, typically produced in mammalian or insect cell systems, is utilized to study its biochemical properties, substrate specificity, and interactions. Structural analyses and knockout models aim to clarify its role in metabolic pathways and therapeutic potential. Despite advances, comprehensive mechanistic insights and clinical relevance require further exploration, positioning SLC37A3 as an emerging target in metabolic and oncogenic research.
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