| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLC38A2 |
| Uniprot No | Q96QD8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-506 aa |
| 活性数据 | MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH |
| 分子量 | 81.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人SLC38A2蛋白的参考文献示例(注：以下为虚构示例，仅用于展示格式，实际文献需根据数据库查询)：
1. **文献名称**: "SLC38A2-mediated amino acid transport supports tumor growth via mTORC1 signaling"
**作者**: Zhang et al. (2021)
**摘要**: 研究揭示了SLC38A2在肿瘤微环境中通过转运谷氨酰胺和丙氨酸激活mTORC1通路，促进癌细胞增殖的作用，并验证了重组SLC38A2蛋白的转运活性。
2. **文献名称**: "Structural insights into the pH-dependent transport mechanism of human SLC38A2"
**作者**: Lee & Kim (2022)
**摘要**: 通过冷冻电镜解析SLC38A2蛋白的分子结构，阐明其依赖pH值的氨基酸转运机制，重组蛋白功能实验验证了底物特异性。
3. **文献名称**: "SLC38A2 regulates synaptic glutamine homeostasis and Alzheimer's disease pathology"
**作者**: Chen et al. (2020)
**摘要**: 发现SLC38A2在小脑神经元中调控突触谷氨酰胺水平，重组蛋白实验表明其功能缺陷与β-淀粉样蛋白沉积相关。
4. **文献名称**: "SLC38A2 as a metabolic checkpoint in obesity-associated insulin resistance"
**作者**: Rodriguez et al. (2023)
**摘要**: 研究肥胖模型中SLC38A2在脂肪组织中的表达变化，通过重组蛋白重建实验证明其调控胰岛素敏感性的潜在机制。
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**注意**：以上文献为模拟示例，实际引用请通过PubMed、Web of Science等数据库查询真实研究。建议使用关键词"SLC38A2 recombinant protein"或"SLC38A2 function"进行检索。
**Background of Recombinant Human SLC38A2 Protein**
The recombinant human SLC38A2 protein, encoded by the *SLC38A2* gene, belongs to the solute carrier family 38 (SLC38), a group of amino acid transporters. SLC38A2. also known as SNAT2. functions as a sodium-coupled neutral amino acid transporter, primarily mediating the uptake of small neutral amino acids like glutamine, alanine, and serine. It plays a pivotal role in cellular nutrient sensing, metabolic regulation, and mTOR signaling, linking amino acid availability to cell growth and proliferation.
This transmembrane protein is ubiquitously expressed, with elevated levels in tissues with high metabolic demands, such as the liver, brain, and certain cancers. Its dysregulation is implicated in pathologies including cancer progression (via supporting tumor cell metabolism) and neurological disorders. Recombinant SLC38A2 is typically produced using heterologous expression systems (e.g., mammalian cells or *E. coli*), enabling studies on its structure, transport mechanisms, and interaction with signaling pathways. Its recombinant form is critical for *in vitro* assays, drug discovery targeting metabolic diseases, and understanding amino acid homeostasis in health and disease. Research continues to explore its therapeutic potential as a biomarker or drug target.
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