| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLC45A2 |
| Uniprot No | Q9UMX9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 0 |
| 活性数据 | MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH |
| 分子量 | 51.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SLC45A2蛋白的3-4篇参考文献的简要概括(文献信息为假设性示例，仅供参考)：
1. **文献名称**: *Functional characterization of recombinant human SLC45A2 in melanin synthesis*
**作者**: Costin, G.E. et al.
**摘要**: 研究通过重组表达SLC45A2蛋白，发现其在黑色素生成中调控酪氨酸酶活性，影响真黑素与褐黑素的比例，并揭示了特定突变导致蛋白功能丧失的机制。
2. **文献名称**: *Structural insights into SLC45A2 using recombinant protein crystallography*
**作者**: Shibata, T. et al.
**摘要**: 利用昆虫细胞系统重组表达并纯化SLC45A2蛋白，通过X射线晶体学解析其三维结构，发现其跨膜结构域中的关键氨基酸对底物转运的贡献。
3. **文献名称**: *SLC45A2 mutations and expression in oculocutaneous albinism*
**作者**: Grønskov, K. et al.
**摘要**: 通过构建重组SLC45A2突变体，揭示其在白化病患者中的功能缺陷，证明该蛋白在黑色素体pH调节中的作用，为疾病机制提供分子证据。
4. **文献名称**: *Recombinant SLC45A2 as a potential drug transporter: in vitro assays*
**作者**: Chen, L. et al.
**摘要**: 利用哺乳动物细胞表达重组SLC45A2.发现其可能参与特定化疗药物的跨膜转运，提示其在药物代谢和耐药性中的潜在作用。
注：以上文献信息为示例性质，具体内容需根据实际发表的论文调整。建议通过PubMed、Google Scholar等平台检索真实文献。
SLC45A2 (Solute Carrier Family 45 Member 2), also known as MATP or AIM1. is a transmembrane protein predominantly involved in melanin synthesis. It belongs to the sugar transporter family but primarily functions as a transporter mediating the uptake of substrates required for melanogenesis within melanosomes, specialized organelles in melanocytes. This protein is crucial for determining pigmentation in human skin, hair, and eyes by regulating the pH and trafficking of tyrosinase, a key enzyme in melanin production.
Mutations in the SLC45A2 gene are linked to oculocutaneous albinism type 4 (OCA4), a genetic disorder characterized by reduced melanin biosynthesis, leading to hypopigmentation, visual impairments, and increased sun sensitivity. Additionally, SLC45A2 variants are associated with population-specific differences in skin color and have been studied in melanoma and vitiligo due to their roles in melanocyte dysfunction.
Recombinant human SLC45A2 protein is widely used to investigate its structure-function relationships, disease mechanisms, and therapeutic targets. It enables in vitro studies of mutant forms, melanosome biology, and interactions with other melanogenic proteins. Research also explores its potential in drug screening for pigmentary disorders or cancers linked to melanin pathways.
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