| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SYNGR2 |
| Uniprot No | O43760 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 168-224 aa |
| 活性数据 | QRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGYQPPPVY |
| 分子量 | 7.9kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于人SYNGR2蛋白的研究文献摘要示例(注：部分文献信息为模拟示例，实际引用需核对真实数据库)：
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**1. "SYNGR2 Regulates Neurite Outgrowth Through Modulation of Vesicle Trafficking"**
*Zhang L, et al. (2020). Journal of Cell Science*
研究报道SYNGR2通过调控突触小泡运输影响神经元的轴突生长。利用重组SYNGR2蛋白进行体外实验，发现其与SNARE复合物相互作用，促进囊泡融合，提示其在神经发育中的功能。
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**2. "Structural Characterization of Human SYNGR2 Reveals a Membrane-binding Domain Critical for Endosomal Sorting"**
*Kim H, et al. (2018). Structure*
通过重组表达纯化人SYNGR2蛋白并进行X射线晶体学分析，揭示其N端膜结合结构域在细胞内吞体分选中的作用，为理解其参与膜运输机制提供结构基础。
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**3. "SYNGR2 Dysregulation Promotes Cancer Metastasis via Exosome-mediated Signaling"**
*Wang Y, et al. (2021). Oncogene*
该研究发现肿瘤细胞中SYNGR2表达上调，重组蛋白实验表明其通过调控外泌体释放促进肿瘤转移，潜在机制涉及MAPK信号通路激活。
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如需具体文献，建议在PubMed或Web of Science中以“SYNGR2 recombinant human”或“SYNGR2 membrane trafficking”为关键词检索最新论文。
Synaptogyrin-2 (SYNGR2) is a member of the synaptogyrin family, a group of small integral membrane proteins predominantly expressed in neuronal and endocrine tissues. It is encoded by the *SYNGR2* gene in humans and shares structural homology with its paralog, SYNGR1. Characterized by four transmembrane domains, SYNGR2 localizes to synaptic vesicles and endosomal compartments, suggesting a role in membrane trafficking and vesicle dynamics. Though its exact molecular mechanisms remain under investigation, SYNGR2 is implicated in modulating synaptic vesicle recycling, neurotransmitter release, and intracellular signaling. Studies link it to the regulation of calcium-dependent exocytosis and interactions with proteins involved in synaptic plasticity, such as synaptophysin and Rab GTPases.
Emerging evidence highlights SYNGR2’s involvement in neurological and neurodevelopmental disorders. Altered expression or mutations in *SYNGR2* have been associated with schizophrenia, autism spectrum disorders, and Alzheimer’s disease, potentially affecting synaptic integrity and neuronal communication. Additionally, its dysregulation is observed in certain cancers, implying broader roles in cell proliferation and apoptosis. Despite functional overlap with SYNGR1. SYNGR2 exhibits distinct expression patterns and binding partners, indicating specialized roles in specific cellular contexts. Current research focuses on elucidating its interaction networks, post-translational modifications, and potential as a therapeutic target. Its conserved structure across vertebrates underscores its evolutionary significance in maintaining synaptic and cellular homeostasis.
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