| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TCP11L2 |
| Uniprot No | Q8N4U5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-519 aa |
| 活性数据 | MPFNGEKQCV GEDQPSDSDS SRFSESMASL SDYECSRQSF ASDSSSKSSS PASTSPPRVV TFDEVMATAR NLSNLTLAHE IAVNENFQLK QEALPEKSLA GRVKHIVHQA FWDVLDSELN ADPPEFEHAI KLFEEIREIL LSFLTPGGNR LRNQICEVLD TDLIRQQAEH SAVDIQGLAN YVISTMGKLC APVRDNDIRE LKATGNIVEV LRQIFHVLDL MQMDMANFTI MSLRPHLQRQ LVEYERTKFQ EILEETPSAL DQTTEWIKES VNEELFSLSE SALTPGAENT SKPSLSPTLV LNNSYLKLLQ WDYQKKELPE TLMTDGARLQ ELTEKLNQLK IIACLSLITN NMVGAITGGL PELASRLTRI SAVLLEGMNK ETFNLKEVLN SIGIQTCVEV NKTLMERGLP TLNAEIQANL IGQFSSIEEE DNPIWSLIDK RIKLYMRRLL CLPSPQKCMP PMPGGLAVIQ QELEALGSQY ANIVNLNKQV YGPFYANILR KLLFNEEAMG KVDASPPTN |
| 分子量 | 58.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TCP11L2蛋白的3条模拟参考文献示例，供参考：
1. **文献名称**: *Molecular Cloning and Expression Profiling of Human TCP11L2 in Male Germ Cells*
**作者**: Smith A, et al.
**摘要**: 研究报道了TCP11L2基因的克隆及其在人类睾丸组织中的特异性表达，发现该蛋白在精子形成过程中可能与减数分裂调控相关，重组蛋白在体外实验中被成功表达并用于抗体开发。
2. **文献名称**: *Functional Analysis of TCP11L2 in Sperm-Egg Fusion Using Recombinant Protein Models*
**作者**: Tanaka K, et al.
**摘要**: 通过重组TCP11L2蛋白的体外功能实验，发现其可能通过结合卵母细胞表面受体参与精卵融合过程，为不孕症的机制研究提供了潜在靶点。
3. **文献名称**: *Structural Insights into TCP11L2 Interaction with Actin Filaments via Cryo-EM*
**作者**: Garcia R, et al.
**摘要**: 利用冷冻电镜解析了重组TCP11L2蛋白的三维结构，揭示了其与肌动蛋白微丝结合的特定结构域，提示其在细胞骨架重塑中的潜在作用。
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注：以上文献为示例，实际研究中请以真实数据库(如PubMed、Web of Science)检索结果为准。如需进一步文献检索指导，请提供更多上下文。
The recombinant human TCP11L2 (t-complex 11-like 2) protein is a genetically engineered form of a naturally occurring protein encoded by the TCP11L2 gene, located on chromosome 1p36.33. TCP11L2 belongs to the t-complex protein 11 (TCP11) family, which shares structural homology with proteins involved in spermatogenesis and cellular interactions. The native TCP11L2 is predominantly expressed in the testis, suggesting a potential role in male reproductive biology, particularly sperm maturation or function. Structurally, it contains coiled-coil domains, which may mediate protein-protein interactions critical for its biological activity.
Recombinant TCP11L2 is typically produced in bacterial or mammalian expression systems, allowing researchers to study its biochemical properties and interactions in vitro. It has garnered interest in reproductive health research due to its testis-specific expression pattern and potential links to infertility. Additionally, emerging studies suggest TCP11L2 may function as a cancer-testis antigen (CTA), with aberrant expression observed in certain malignancies like prostate and breast cancers. This has spurred exploration of its utility as a biomarker or therapeutic target in oncology.
Beyond disease research, recombinant TCP11L2 serves as a tool for antibody development, structural analysis, and elucidating molecular pathways in gametogenesis. However, its precise physiological mechanisms remain under investigation, highlighting the need for further functional studies.
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