| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZMYM6 |
| Uniprot No | O95789 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-156 aa |
| 活性数据 | MKEPLDGECGKAVVPQQELLDKIKEEPDNAQEYGCVQQPKTQESKLKIGGVSSVNERPIAQQLNPGFQLSFASSGPSVLLPSVPAVAIKVFCSGCKKMLYKGQTAYHKTGSTQLFCSTRCITRHSSPACLPPPPKKTCTNCSKYKILNIPFYFTFF |
| 分子量 | 42.79 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZMYM6蛋白的3篇模拟参考文献及其摘要概括：
1. **文献名称**: *"ZMYM6 interacts with the LSD1/CoREST complex and regulates histone demethylation in transcriptional repression"*
**作者**: Smith J, et al. (2020)
**摘要**: 该研究利用重组人ZMYM6蛋白进行体外结合实验，发现其通过N端锌指结构域与LSD1/CoREST复合物相互作用，协同抑制靶基因表达，并参与组蛋白H3K4去甲基化调控。
2. **文献名称**: *"Structural characterization of the ZMYM6 FNIII domain reveals its role in chromatin remodeling"*
**作者**: Johnson R, et al. (2021)
**摘要**: 通过重组表达并纯化人ZMYM6蛋白的FNIII结构域，结合X射线晶体学解析其三维结构，揭示了该结构域在介导染色质重塑复合物组装中的关键作用。
3. **文献名称**: *"ZMYM6 promotes glioblastoma progression via stabilizing recombinant protein interaction networks"*
**作者**: Lee H, et al. (2019)
**摘要**: 研究利用重组ZMYM6蛋白进行功能获得实验，发现其在胶质母细胞瘤中通过稳定致癌蛋白相互作用网络(如EGFR信号通路)促进肿瘤细胞增殖和侵袭。
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注：以上内容基于假设性文献构建，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
ZMYM6 (Zinc Finger MYM-Type Containing 6) is a human protein belonging to the MYM (MYND domain and zinc fingers) family, characterized by the presence of MYM-type zinc finger domains. These domains are critical for mediating protein-protein or protein-DNA interactions, suggesting a role in transcriptional regulation or chromatin remodeling. Structurally, ZMYM6 contains multiple C2HC zinc fingers and coiled-coil regions, which may facilitate its integration into multiprotein complexes. It is predominantly localized in the nucleus, aligning with its potential involvement in epigenetic processes.
Functionally, ZMYM6 has been linked to chromatin modification and DNA repair pathways. While its exact mechanisms remain understudied, studies suggest it interacts with histone deacetylases (HDACs) and other transcriptional co-repressors, implying a role in gene silencing or maintaining heterochromatin stability. Emerging evidence connects ZMYM6 to cellular differentiation and proliferation, particularly in hematopoietic and neural systems. Dysregulation of ZMYM6 has been observed in certain cancers, such as leukemia and gliomas, where altered expression correlates with disease progression. However, its classification as an oncogene or tumor suppressor remains ambiguous, necessitating further research.
Despite its biological significance, ZMYM6 is less characterized compared to other MYM family members like ZMYM2 or ZMYM3. Current research focuses on elucidating its interaction networks and involvement in specific signaling pathways. Understanding ZMYM6 could provide insights into epigenetic disorders and cancer biology, offering potential therapeutic targets.
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