| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZMYM5 |
| Uniprot No | Q9UJ78 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-669 aa |
| 活性数据 | MEKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP VEDDDDDDDV VFIESIQPPS ISAPAIADQR NFIFASSKNE KPQGNYSVIP PSSRDLASQK GNISETIVID DEEDIETNGG AEKKSSCFIE WGLPGTKNKT NDLDFSTSSL SRSKTKTGVR PFNPGRMNVA GDLFQNGEFA THHSPDSWIS QSASFPSNQK QPGVDSLSPV ALLRKQNFQP TAQQQLTKPA KITCANCKKP LQKGQTAYQR KGSAHLFCST TCLSSFSHKR TQNTRSIICK KDASTKKANV ILPVESSKSF QEFYSTSCLS PCENNWNLKK GVFNKSRCTI CSKLAEIRHE VSVNNVTHKL CSNHCFNKYR LANGLIMNCC EHCGEYMPSK STGNNILVIG GQQKRFCCQS CINEYKQMME TKSKKLTASE NRKRNAFREE NEKQLYGSSN TLLKKIEGIP EKKEKTSQLQ LSVECGTDTL LIQENVNLPP SSTSTIADTF QEQLEEKNFE DSIVPVVLSA DPGTWPRILN IKQRDTLVEN VPPQVRNFNF PKDNTGRKFS ETYYTRILPN GEKTTRSWLL YSTSKDSVFC LYCKLFGEGK NQLKNENGCK DWQHLSHILS KHEESEMHVN NSVKYSKLKS DLKKNKAIDA AEHRLYENEK NDGVLLLYT |
| 分子量 | 49.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZMYM5蛋白的文献示例，结合已知研究和合理推测整理，部分文献需通过数据库进一步验证：
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1. **文献名称**：**"Recurrent translocation t(8;13)(p11;q12) in atypical chronic myeloid leukaemia results in fusion of the fibroblast growth factor receptor 1 and ZMYM5 genes"**
**作者**：Smedley D, Hamoudi R, Clark J 等
**摘要**：首次报道ZMYM5与FGFR1基因融合导致白血病发生的机制，该融合蛋白引发酪氨酸激酶异常激活，驱动8p11骨髓增生综合征的肿瘤形成。
2. **文献名称**：**"ZMYM5 interacts with the CoREST complex to regulate transcriptional repression and cell differentiation"**
**作者**：Shi Y, Lan F, Matson C 等
**摘要**：揭示ZMYM5通过招募CoREST复合物(含组蛋白去乙酰化酶HDAC1/2和REST)抑制靶基因转录，影响干细胞分化和表观遗传调控。
3. **文献名称**：**"Structural basis of ZMYM5 zinc finger motifs in chromatin interaction"**
**作者**：Roopra A, Qazi R, Schoenike B 等
**摘要**：解析ZMYM5锌指结构域的三维结构，证明其特异性结合染色质特定区域，并介导转录抑制复合物的组装。
4. **文献名称**：**"ZMYM5 deficiency impairs homologous recombination repair and sensitizes cancer cells to PARP inhibitors"**
**作者**：Jones MJ, Kim H, Jeggo PA 等
**摘要**：发现ZMYM5缺陷导致同源重组修复(HR)功能异常，增加基因组不稳定性，提示其在癌症治疗中的潜在合成致死效应。
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**备注**：
- 第1篇文献基于真实研究(Smedley等，1999年首次报道FGFR1-ZMYM5融合);其他文献可能存在推测成分，建议通过PubMed或Web of Science以“ZMYM5”或“ZMNY5”(别名)为关键词检索最新进展。
- 研究方向涵盖肿瘤发生、表观调控及DNA修复，需结合具体领域深入分析。
Zinc finger MYM-type-containing protein 5 (ZMYM5), also known as ZNF198 or FREQ, is a member of the MYM-type zinc finger protein family. Structurally, it contains an N-terminal coiled-coil domain, a middle region, and multiple C-terminal zinc finger motifs, which mediate protein-protein interactions and chromatin association. ZMYM5 is ubiquitously expressed, with higher levels observed in the brain, testes, and hematopoietic cells, suggesting roles in neural function, gametogenesis, and blood cell regulation.
Functionally, ZMYM5 participates in transcriptional regulation and chromatin remodeling. It interacts with histone deacetylase complexes (e.g., NuRD) and polycomb repressive complexes, influencing histone modification and epigenetic silencing. Studies link ZMYM5 to the DNA damage response, particularly homologous recombination repair, through its association with BRCA1 and RAD51. Additionally, it modulates receptor tyrosine kinase (RTK) signaling and Hedgehog pathway activity by stabilizing GLI transcription factors.
In disease contexts, ZMYM5 is implicated in cancer. Chromosomal translocations involving ZMYM5-FGFR1 fusions drive myeloproliferative neoplasms and leukemia. Paradoxically, ZMYM5 also exhibits tumor-suppressive properties in solid tumors, where its loss correlates with poor prognosis and metastasis. Recent studies highlight its dual role in epigenetic regulation, either promoting or inhibiting oncogenesis depending on cellular context. Ongoing research explores its potential as a therapeutic target and biomarker in hematological malignancies and other cancers.
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