| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZMYND11 |
| Uniprot No | Q15326 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-602 aa |
| 活性数据 | MARLTKRRQA DTKAIQHLWA AIEIIRNQKQ IANIDRITKY MSRVHGMHPK ETTRQLSLAV KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EIDWETENHD WYCFECHLPG EVLICDLCFR VYHSKCLSDE FRLRDSSSPW QCPVCRSIKK KNTNKQEMGT YLRFIVSRMK ERAIDLNKKG KDNKHPMYRR LVHSAVDVPT IQEKVNEGKY RSYEEFKADA QLLLHNTVIF YGADSEQADI ARMLYKDTCH ELDELQLCKN CFYLSNARPD NWFCYPCIPN HELVWAKMKG FGFWPAKVMQ KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS MGWKKACDEL ELHQRFLREG RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR NQSVEPKKEE PEPETEAVSS SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND GVCQSMCHDK YTKIFNDFKD RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM QGEMDRKCKQ VKEKCKEEFV EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY CSIKCQQEHW HAEHKRTCRR KR |
| 分子量 | 70.963 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZMYND11蛋白的3篇代表性文献示例，涵盖其结构、功能及疾病相关性：
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1. **文献名称**: *ZMYND11 is a novel obligate partner of BRD4 in transcriptional activation*
**作者**: Wang F et al. (2018)
**摘要**: 揭示了ZMYND11与染色质调控因子BRD4的直接相互作用，阐明其通过招募组蛋白去乙酰化酶复合体(HDACs)调控靶基因转录抑制的机制，在白血病中表现出肿瘤抑制作用。
2. **文献名称**: *Structural basis for recognition of methylated histone H3K36 by the DNA repair protein ZMYND11*
**作者**: Guo R et al. (2016)
**摘要**: 通过X射线晶体学解析ZMYND11的串联植物同源结构域(PHD)如何特异性识别组蛋白H3K36me3修饰，提出其通过表观遗传调控参与DNA损伤修复及癌症抑制的分子机制。
3. **文献名称**: *ZMYND11 knockdown promotes glioblastoma metastasis through activating AKT/mTOR signaling*
**作者**: Liu Y et al. (2020)
**摘要**: 在胶质母细胞瘤模型中，证实ZMYND11缺失通过激活AKT/mTOR通路促进肿瘤侵袭，重组ZMYND11蛋白回补实验可逆转该表型，提示其作为转移抑制因子的潜在治疗价值。
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*注：以上文献标题及作者为示例性质，具体研究请以实际发表的论文数据为准。建议通过PubMed等数据库以“ZMYND11”为关键词检索最新文献。*
**Background of Recombinant Human ZMYND11 Protein**
ZMYND11 (Zinc Finger MYND Domain-Containing Protein 11) is a multidomain protein encoded by the *ZMYND11* gene, located on human chromosome 10q11.23. It belongs to the MYND protein family, characterized by a conserved MYND domain that mediates protein-protein interactions, particularly with transcriptional coregulators. Structurally, ZMYND11 contains additional functional domains, including PHD zinc fingers and a bromodomain, which are critical for chromatin binding and epigenetic regulation. These domains enable ZMYND11 to act as a scaffold, linking histone modification readers (e.g., bromodomains) with chromatin remodelers or transcriptional machinery.
Functionally, ZMYND11 is implicated in transcriptional repression, DNA damage response, and neuronal development. Studies suggest it acts as a tumor suppressor by regulating expression of genes involved in cell cycle arrest, apoptosis, and metastasis inhibition. In neurons, ZMYND11 supports synaptic function and neurodevelopment, with its dysfunction linked to intellectual disabilities and neurodevelopmental disorders.
Recombinant ZMYND11 protein, produced via expression systems like *E. coli* or mammalian cells, is crucial for studying its biochemical properties, interactions, and role in disease. It serves as a tool to explore mechanisms underlying cancer, neurodegeneration, and chromatin biology. Research on ZMYND11 may advance therapeutic strategies targeting epigenetic pathways or neurodevelopmental disorders.
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