| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF207 |
| Uniprot No | O43670 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-478 aa |
| 活性数据 | MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL AIHCMQVHKE TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK TQESQKKKQQ DDSDEYDDDD SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG MPPGMMPMGG MMPPGPGIPP LMPGMPPGMP PPVPRPGIPP MTQAQAVSAP GILNRPPAPT ATVPAPQPPV TKPLFPSAGQ MGTPVTSSST ASSNSESLSA SSKALFPSTA QAQAAVQGPV GTDFKPLNST PATTTEPPKP TFPAYTQSTA STTSTTNSTA AKPAASITSK PATLTTTSAT SKLIHPDEDI SLEERRAQLP KYQRNLPRPG QAPIGNPPVG PIGGMMPPQP GIPQQQGMRP PMPPHGQYGG HHQGMPGYLP GAMPPYGQGP PMVPPYQGGP PRPPMGMRPP VMSQGGRY |
| 分子量 | 50.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF207蛋白的3篇参考文献示例(注：文献为假设性示例，实际引用需核实真实来源)：
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1. **文献名称**: **ZNF207 promotes cell proliferation by regulating G2/M transition in cancer cells**
**作者**: Zhang Y, et al.
**摘要**: 本研究通过重组人ZNF207蛋白体外实验，发现其通过结合CDK1并稳定Cyclin B1蛋白，调控肿瘤细胞G2/M期转换，促进结肠癌细胞增殖。敲低ZNF207导致细胞周期阻滞并抑制肿瘤生长。
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2. **文献名称**: **Structural and functional analysis of recombinant human ZNF207 in stem cell differentiation**
**作者**: Kim S, et al.
**摘要**: 文章报道了利用大肠杆菌系统表达重组ZNF207蛋白，并解析其锌指结构域的结合特性。实验表明ZNF207通过调控多能性基因(如OCT4)的转录，影响胚胎干细胞的自我更新与分化。
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3. **文献名称**: **ZNF208/ZNF207 complex modulates cardiac hypertrophy via PI3K/AKT signaling**
**作者**: Wang L, et al.
**摘要**: 研究发现重组ZNF207蛋白与ZNF208形成复合物，通过激活PI3K/AKT通路加重心肌细胞病理性肥大，靶向该复合物可能为心力衰竭提供潜在治疗策略。
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如需真实文献，建议在PubMed或Web of Science检索关键词“ZNF207 recombinant”或“ZNF207 function”。
Zinc finger protein 207 (ZNF207), also known as hDZIP1 or ZFP207. is a member of the Krüppel-associated box (KRAB)-containing zinc finger protein family, which plays regulatory roles in transcription, chromatin remodeling, and cellular differentiation. This protein contains multiple C2H2-type zinc finger domains that enable sequence-specific DNA or RNA binding, along with protein interaction motifs. ZNF207 is evolutionarily conserved and ubiquitously expressed in human tissues, with particularly high levels observed in the heart, skeletal muscle, and testis.
Functionally, ZNF207 has been implicated in cell cycle regulation, specifically during mitosis. Studies suggest its involvement in maintaining genomic stability through interactions with centrosomal proteins and components of the mitotic apparatus. It participates in spindle assembly checkpoint signaling and cytokinesis by regulating Aurora kinase B activity and proper chromosome segregation. Recent research highlights its oncogenic potential, as elevated ZNF207 expression correlates with poor prognosis in various cancers, including hepatocellular carcinoma and colorectal cancer. The protein appears to promote tumor progression by enhancing cell proliferation, inhibiting apoptosis, and facilitating epithelial-mesenchymal transition.
Recombinant ZNF207 protein, typically produced in bacterial or mammalian expression systems, serves as a crucial tool for investigating its molecular functions, DNA-binding specificity, and therapeutic targeting potential in disease models.
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