关键信息
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基因名
TACC3
- 应用
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别名
ERIC 1; ERIC-1; ERIC1; MGC117382; MGC133242; OTTHUMP00000113796; TACC3; TACC3_HUMAN; Transforming acidic coiled coil containing protein 3; Transforming acidic coiled-coil-containing protein 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6A5
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表达区间
1-100 aa
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氨基酸序列
MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTPLRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQK
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分子量
36.74kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The TACC3 protein, part of the transforming acidic coiled-coil (TACC) family, plays a crucial role in cell division and maintaining genomic stability. It is characterized by its involvement in organizing the mitotic spindle, ensuring proper chromosome alignment during mitosis. Dysregulation or overexpression of TACC3 has been linked to various cancers, making it a potential biomarker for tumor progression and a target for therapeutic intervention. Recent studies have revealed that TACC3 interacts with numerous cellular pathways, including those regulating microtubule dynamics and centrosome function. As a result, understanding the precise mechanisms of TACC3 function and its contributions to oncogenesis has become a significant focus of cancer research. By investigating TACC3's structural properties and its interactions at the molecular level, researchers aim to uncover novel strategies for cancer treatment while enhancing our fundamental understanding of cell cycle regulation. Through these studies, TACC3 not only emerges as a vital player in mitotic processes but also as a promising target in the quest for innovative cancer therapies.
