| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDH26 |
| Uniprot No | Q8IXH8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-832aa |
| 氨基酸序列 | MAMRSGRHPSLLLLLVLLLWLLQVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQGVKDLEEVPPSAASQSAQARCALGSWGYGKPFEPRSVKNIHSTPAYPDATMHRQLLAPVEGRMAETLNQKLHVANVLEDDPGYLPHVYSEEGECGGAPSLSSLASLEQELQPDLLDSLGSKATPFEEIYSESGVPS |
| 预测分子量 | 92,4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CDH26重组蛋白的虚构参考文献示例(基于研究领域常见方向)：
1. **文献名称**：*CDH26 Functions as an Epithelial-Specific Receptor for Rhinovirus C*
**作者**：Smith J, et al.
**摘要内容**：本研究揭示了CDH26作为鼻病毒C(RV-C)的宿主受体，通过重组蛋白表达和体外结合实验证实其直接相互作用，为呼吸道病毒感染机制提供了新靶点。
2. **文献名称**：*Structural Characterization of Recombinant CDH26 and Its Role in Eosinophilic Inflammation*
**作者**：Lee H, et al.
**摘要内容**：通过X射线晶体学解析了CDH26重组蛋白的胞外结构域，发现其介导嗜酸性粒细胞与上皮细胞黏附，提示CDH26在哮喘等Th2型炎症中的调控作用。
3. **文献名称**：*CDH26-Based Therapeutic Peptides Attenuate Allergic Airway Hyperresponsiveness*
**作者**：Wang Y, et al.
**摘要内容**：利用CDH26重组蛋白筛选出阻断其与整合素相互作用的肽段，动物实验显示可减轻气道高反应性，为过敏性疾病治疗提供新策略。
4. **文献名称**：*CDH26 Expression in Gastrointestinal Tumors and Its Immunomodulatory Effects*
**作者**：Garcia R, et al.
**摘要内容**：分析CDH26在消化道肿瘤中的异常表达，并通过重组蛋白实验证明其调节T细胞活性，提示其双重角色(促癌或抑癌)可能依赖微环境信号。
(注：以上文献为示例性质，实际研究中请通过PubMed等数据库检索真实发表论文。)
CDH26. also known as cadherin-26. is a member of the cadherin superfamily of calcium-dependent cell adhesion proteins. It is a type II classical cadherin characterized by extracellular cadherin (EC) repeats that mediate homophilic or heterophilic interactions, a transmembrane domain, and a cytoplasmic tail linked to intracellular signaling. CDH26 is expressed in various tissues, including the respiratory and gastrointestinal tracts, and has garnered interest for its dual roles in cell adhesion and immune regulation. Studies suggest it participates in epithelial barrier maintenance and modulates immune cell interactions, particularly in inflammatory contexts.
In the immune system, CDH26 is notably expressed on epithelial cells and subsets of immune cells, such as eosinophils. It interacts with integrins (e.g., α4β7) and may regulate leukocyte trafficking, adhesion, and activation. This interaction positions CDH26 as a potential mediator in allergic inflammation, asthma, and inflammatory bowel disease (IBD). For example, in asthma, CDH26 overexpression correlates with eosinophil infiltration, while in IBD, it may influence mucosal immune responses.
Recombinant CDH26 protein is typically produced in mammalian expression systems (e.g., HEK293 or CHO cells) to ensure proper post-translational modifications. It often includes an Fc-tag for purification and functional studies. Researchers utilize this protein to investigate ligand-receptor interactions, screen therapeutic antibodies, or explore its role as a biomarker. Preclinical studies highlight its therapeutic potential: blocking CDH26-integrin pathways may suppress inflammation, while its adhesive properties could be harnessed for tissue repair. Ongoing research aims to clarify its mechanistic nuances and translational applications in immune-mediated diseases.
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