| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SYNPO |
| Uniprot No | Q8N3V7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-929aa |
| 氨基酸序列 | MLGPHLPPPPLAPSEGRPTPCAFQIPDGSYRCLALEAEESSGEEGLQGEVGPTDLEEDEGVSRSGDDSACRVTQGTPQLPKALGIQPPSCSREEQGASQHDDRASQDWDVVKAGQMMTASPSPGPGPRVAQKPALGRSTSLTEKDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESHGQRGQKPSQESLRVLPSSLPGHAPGLSLSSTSLPEPGPPRHPSPQSPDRGVPGHSMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK |
| 预测分子量 | 99,4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **SYNPO(Synaptopodin)重组蛋白** 的3篇参考文献及其简要摘要：
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1. **文献名称**: *Synaptopodin: An Actin-associated Protein in Telencephalic Dendrites and Renal Podocytes*
**作者**: Mundel, P., et al.
**摘要**: 研究首次克隆并鉴定了Synaptopodin(SYNPO)在肾足细胞和神经元树突中的表达，揭示了其与肌动蛋白细胞骨架的相互作用，并提示其在调节细胞形态和运动中的关键作用。
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2. **文献名称**: *Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons*
**作者**: Deller, T., et al.
**摘要**: 探讨SYNPO在神经元突触可塑性中的功能，发现SYNPO通过稳定肌动蛋白网络调控树突棘的动态重塑，缺失SYNPO会导致海马依赖性记忆障碍。
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3. **文献名称**: *Loss of Synaptopodin in glomerular disease correlates with proteinuria and cytoskeletal changes*
**作者**: Faul, C., et al.
**摘要**: 分析肾小球疾病(如局灶节段性肾小球硬化)中SYNPO的表达缺失，证明其与足细胞损伤、细胞骨架紊乱及蛋白尿的病理关联，提示SYNPO是肾脏保护性标志物。
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**备注**：以上文献为示例性质，具体内容需根据实际研究调整。建议通过PubMed或Google Scholar以关键词“Synaptopodin recombinant protein”或“SYNPO function”检索最新研究。
Synaptopodin (SYNPO) is a cytoskeleton-associated protein predominantly expressed in renal podocytes and neuronal dendrites, where it plays a critical role in maintaining cellular structure and function. It was first identified as a marker of differentiated podocytes, specialized cells in the kidney glomerulus essential for filtration. In neurons, SYNPO localizes to synaptic spines, influencing synaptic plasticity and dendritic organization. The protein interacts with actin filaments and α-actinin, bridging the cytoskeleton with membrane signaling complexes. Its structural domains, including proline-rich motifs and binding sites for actin-regulating proteins, enable it to modulate cytoskeletal dynamics, cell motility, and membrane stability.
In kidney disease, SYNPO deficiency or dysfunction is linked to proteinuria and glomerular disorders, as disrupted podocyte architecture compromises filtration. Similarly, in neurodegenerative contexts, SYNPO dysregulation correlates with synaptic spine loss and impaired cognitive function. Recombinant SYNPO proteins, produced via bacterial or eukaryotic expression systems, are vital tools for studying these mechanisms. They enable in vitro exploration of protein-protein interactions, post-translational modifications (e.g., phosphorylation), and pathological mutations. Researchers also use recombinant SYNPO to generate antibodies, develop diagnostic assays, or model diseases in cellular systems. Its therapeutic potential, such as targeting podocyte repair or synaptic regeneration, remains an active area of investigation. Overall, SYNPO exemplifies a multifunctional adaptor protein whose recombinant forms accelerate both basic research and translational applications in nephrology and neuroscience.
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