| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TZ |
| Uniprot No | Q08380 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-585aa |
| 氨基酸序列 | MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQFNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTDSSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSLVYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGWKAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD |
| 预测分子量 | 65,3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TZ重组蛋白的虚构参考文献示例，格式包含文献名称、作者及摘要概括：
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1. **文献名称**: *Efficient Expression and Functional Characterization of Recombinant TZ Protein in E. coli*
**作者**: Zhang L., Wang Y., et al.
**摘要**: 本研究报道了通过大肠杆菌表达系统高效表达TZ重组蛋白的优化方法，利用亲和层析技术纯化获得高纯度蛋白。通过体外活性实验证实，重组TZ蛋白具有显著的酶催化活性，为后续生物医学应用奠定基础。
2. **文献名称**: *Structural Insights into TZ Recombinant Protein by Cryo-EM Analysis*
**作者**: Chen X., Tanaka K., et al.
**摘要**: 采用冷冻电镜技术解析了TZ重组蛋白的三维结构，揭示了其独特的跨膜结构域及潜在的底物结合位点。该结构为理解TZ蛋白在细胞信号转导中的功能机制提供了关键依据。
3. **文献名称**: *Therapeutic Potential of TZ Recombinant Protein in a Mouse Model of Autoimmune Disease*
**作者**: Gupta R., Li H., et al.
**摘要**: 在小鼠自身免疫疾病模型中，注射TZ重组蛋白显著减轻炎症反应并调节免疫细胞活性。研究证明，TZ蛋白通过抑制促炎因子IL-6分泌发挥治疗作用，提示其作为新型生物药物的潜力。
4. **文献名称**: *TZ Recombinant Protein Interaction with Membrane Receptors: A Biophysical Study*
**作者**: Müller S., Zhou W., et al.
**摘要**: 通过表面等离子共振(SPR)技术分析TZ重组蛋白与细胞膜表面受体CD40的结合动力学，发现其高亲和力结合特性。研究阐明了TZ蛋白在免疫调节通路中的分子互作机制。
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注：以上内容为模拟示例，实际文献需通过学术数据库检索确认。
TZ recombinant protein, a engineered biomolecule, represents a significant advancement in modern biotechnology and therapeutic development. Derived through recombinant DNA technology, TZ proteins are typically designed by fusing functional domains from different parent proteins to create novel chimeric structures with enhanced or combined biological activities. The "TZ" designation often refers to specific functional motifs or target indications, though naming conventions may vary across research contexts.
These proteins are commonly produced in heterologous expression systems such as E. coli, yeast, or mammalian cell cultures, depending on required post-translational modifications. Advanced protein engineering techniques, including rational design and directed evolution, are frequently employed to optimize their stability, binding affinity, and specificity. A key feature of TZ recombinant proteins lies in their modular architecture, which allows customizable combinations of receptor-binding domains, enzymatic components, or signaling modules.
Therapeutic applications often focus on targeting specific disease pathways, particularly in oncology and autoimmune disorders. Many TZ variants function as targeted biologics, combining tumor-homing peptides with immune-activating domains to create dual-action therapeutics. In diagnostic applications, engineered TZ proteins serve as high-affinity detection probes in immunoassays due to their improved specificity over conventional antibodies.
Current research explores their potential in drug delivery systems, where TZ proteins act as molecular carriers with tissue-specific targeting capabilities. Challenges remain in balancing immunogenicity profiles and ensuring proper pharmacokinetics, particularly for systemic administration. As structural biology and computational modeling tools advance, TZ recombinant proteins continue to enable precision medicine approaches through their tunable biological functions and mechanism-driven design.
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