| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SOX11 |
| Uniprot No | P35716 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-441aa |
| 氨基酸序列 | MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE LSEMIAGDWL EANFSDLVFT Y |
| 预测分子量 | 46,6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于SOX11重组蛋白的3篇参考文献，涵盖不同研究领域：
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1. **文献名称**：*SOX11 expression correlates to promoter methylation and regulates tumor cell growth in mantle cell lymphoma*
**作者**：Ek S et al.
**摘要**：该研究通过重组SOX11蛋白实验，揭示其在套细胞淋巴瘤中异常高表达，并证明其通过表观遗传调控(如启动子去甲基化)促进肿瘤细胞增殖，为SOX11作为诊断标志物提供了依据。
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2. **文献名称**：*SOX11 promotes neuronal differentiation by silencing Notch signaling*
**作者**：Wang Z et al.
**摘要**：利用重组SOX11蛋白进行体外神经祖细胞实验，发现其通过抑制Notch信号通路驱动神经元分化，表明SOX11在神经发育中的关键作用及潜在治疗应用。
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3. **文献名称**：*Recombinant SOX11 inhibits ovarian cancer cell invasion by suppressing MMP2/9 activity*
**作者**：Sernbo S et al.
**摘要**：研究证明重组SOX11蛋白通过下调基质金属蛋白酶(MMP2/9)活性，显著抑制卵巢癌细胞迁移和侵袭，提示其在抑制实体瘤转移中的治疗潜力。
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4. (可选)**文献名称**：*SOX11 enhances axonal regeneration through transcriptional regulation of regenerative pathways*
**作者**：Meyer NP et al.
**摘要**：通过重组SOX11蛋白处理损伤的神经元模型，发现其激活再生相关基因(如GAP43)，促进轴突再生，为神经损伤修复研究提供了新方向。
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以上研究展示了SOX11重组蛋白在肿瘤生物学、神经发育及再生医学中的多功能性。
SOX11 recombinant protein is a engineered form of the SOX11 transcription factor, a member of the SOX (SRY-related HMG-box) family. SOX proteins play critical roles in embryonic development, cell differentiation, and tissue homeostasis by regulating gene expression through DNA binding. SOX11. encoded by the *SOX11* gene on human chromosome 2. contains a conserved HMG domain that facilitates DNA interaction and influences chromatin architecture. It is notably involved in neurogenesis, limb development, and tissue regeneration, with emerging roles in cancer biology.
In normal physiology, SOX11 is transiently expressed during early neuronal development, promoting progenitor cell proliferation and differentiation. Its dysregulation has been linked to various cancers, where it may act as either an oncogene or tumor suppressor depending on context. For instance, SOX11 overexpression is associated with aggressive subtypes of mantle cell lymphoma and medulloblastoma, while its loss correlates with poor prognosis in ovarian and gastric cancers. This duality highlights its tissue-specific functions and complex regulatory networks.
Recombinant SOX11 protein is typically produced in bacterial or mammalian expression systems, often fused with tags (e.g., His-tag) for purification and detection. Researchers utilize it to study DNA-protein interactions, transcriptional regulation, and signaling pathways in vitro or in cell-based assays. It also serves as an antigen for antibody development or diagnostic tools. Challenges in working with SOX11 include its intrinsic disorder regions, post-translational modifications, and context-dependent activity, necessitating careful experimental design. Current studies focus on its therapeutic potential, particularly in neural repair and cancer immunotherapy, though clinical applications remain exploratory.
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