关键信息
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基因名
IL-17RB
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简介
IL-17RB (Interleukin 17 receptor B), a protein encoded by the IL17RB gene, is a receptor for the pro-inflammatory cytokines IL17B and IL17E. IL-17RB expression is high in kidney, pancreas, liver, brain, and intestines. IL-17RB may play a role in hematopoietic cell differentiation and growth. IL-17RB is involved in inflammatory diseases and cancers[1][2]. IL-17RB Protein, Mouse (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 269 amino acids (R18-G286).
- 应用
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别名
Interleukin-17 receptor B; IL-17RB; IL-17Rh1; IL-17B receptor; CRL4; EVI27
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
Q9JIP3
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表达区间
R18-G286
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氨基酸序列
REPTIQCGSETGPSPEWMVQHTLTPGDLRDLQVELVKTSVAAEEFSILMNISWILRADASIRLLKATKICVSGKNNMNSYSCVRCNYTEAFQSQTRPSGGKWTFSYVGFPVELSTLYLISAHNIPNANMNEDSPSLSVNFTSPGCLNHVMKYKKQCTEAGSLWDPDITACKKNEKMVEVNFTTNPLGNRYTILIQRDTTLGFSRVLENKLMRTSVAIPVTEESEGAVVQLTPYLHTCGNDCIRREGTVVLCSETSAPIPPDDNRRMLGG
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蛋白长度
Extracellular Domain
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分子量
38-45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Interleukin-17 receptor B (IL-17RB) plays a crucial role in the immune response, particularly in defense against various pathogens and in the pathogenesis of inflammatory diseases. Discovered as a receptor for IL-25 (also known as IL-17E), IL-17RB is predominantly expressed in epithelial cells and immune cells, indicating its significant function in mucosal immunity. Its activation triggers downstream signaling pathways, leading to the production of pro-inflammatory cytokines, growth factors, and chemokines, which are vital for recruiting eosinophils and other inflammatory cells to sites of inflammation. Given its central role in mediating Th2-type immune responses, IL-17RB has emerged as a potential therapeutic target for allergic diseases, asthma, and other Th2-mediated conditions. Recent studies have also highlighted its involvement in various cancers, making it a candidate for further research in tumor immunology. The development of recombinant IL-17RB proteins aims to better understand its biological functions and therapeutic potential by enabling researchers to explore its signaling mechanisms, binding affinities, and interactions with other immune modulators. These advancements could pave the way for innovative treatments for IL-17RB-related diseases and enhance our understanding of its role in both protective immunity and pathological inflammation.
