Recombinant Human Susd4 protein

**Background of SUSD4 Recombinant Protein**

SUSD4 (Sushi domain-containing protein 4) is a member of the SUSD protein family, characterized by conserved sushi (or complement control protein) domains. These domains are known to mediate protein-protein and protein-ligand interactions, often playing roles in immune regulation, cell adhesion, and signaling pathways. SUSD4 is a transmembrane protein predominantly expressed in tissues such as the placenta, brain, and immune cells. While its exact biological functions remain under investigation, emerging studies suggest its involvement in modulating cellular processes like apoptosis, immune response, and tumor suppression. For instance, SUSD4 has been linked to the regulation of the complement system and interactions with signaling receptors like NOTCH, hinting at potential roles in developmental and pathological contexts.

Recombinant SUSD4 protein is engineered *in vitro* using expression systems (e.g., mammalian, insect, or bacterial cells) to produce purified, functional SUSD4 for research applications. This recombinant form retains key structural features, including sushi domains, enabling studies on its binding partners, signaling mechanisms, and therapeutic potential. Researchers utilize SUSD4 recombinant protein to explore its role in diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. For example, its alleged tumor-suppressive effects in certain cancers make it a candidate for biomarker discovery or targeted therapy development. Additionally, SUSD4's immunomodulatory properties are being probed for applications in inflammation and vaccine design.

Despite progress, SUSD4's full mechanistic landscape and clinical relevance require further elucidation, driving ongoing interest in recombinant tools to unravel its complex biology.