Mouse Monoclonal EIF2A Antibody

The eukaryotic translation initiation factor 2A (EIF2A) is a protein involved in the initiation phase of protein synthesis, specifically under stress conditions. Unlike its paralog EIF2α, which regulates global translation via phosphorylation during the integrated stress response, EIF2A is thought to mediate non-canonical translation initiation pathways, such as the initiation of specific mRNAs under hypoxia, viral infection, or other cellular stresses. EIF2A antibodies are tools used to study its expression, localization, and functional roles in these contexts. Research suggests EIF2A may contribute to the translation of pro-survival or stress-adaptive proteins, including those with internal ribosome entry sites (IRES). However, its precise mechanisms remain less defined compared to EIF2α. Antibodies targeting EIF2A enable detection via Western blotting, immunofluorescence, or immunoprecipitation, aiding investigations into its involvement in diseases like cancer, neurodegeneration, or viral pathogenesis. Recent studies also explore its potential crosstalk with EIF2α signaling and its role in apoptosis or autophagy regulation. Despite growing interest, EIF2A's biological significance is still under debate, necessitating further research to clarify its regulatory networks and therapeutic relevance.