Mouse Monoclonal AIM2 Antibody

The AIM2 (Absent in Melanoma 2) antibody is a research tool used to study the AIM2 protein, a cytosolic DNA sensor critical in innate immunity. AIM2 belongs to the PYHIN protein family and contains a HIN200 domain for double-stranded DNA binding and a Pyrin domain for inflammasome assembly. Upon detecting pathogenic or self-derived DNA, AIM2 recruits ASC and procaspase-1 to form the AIM2 inflammasome, triggering caspase-1 activation. This promotes pyroptosis (inflammatory cell death) and secretion of pro-inflammatory cytokines like IL-1β and IL-18. AIM2 is implicated in infections, autoimmune diseases (e.g., lupus, psoriasis), and cancer, where its dual role as a tumor suppressor or promoter depends on context. Antibodies targeting AIM2 enable detection of its expression, localization, and interaction partners in cells or tissues via techniques like Western blotting, immunofluorescence, and immunohistochemistry. They also aid in exploring AIM2's therapeutic potential—either by inhibiting its hyperactivity in autoimmune conditions or enhancing its antitumor effects. Current research focuses on clarifying AIM2's disease-specific mechanisms and validating its clinical relevance, though most applications remain preclinical. These antibodies are vital for advancing understanding of inflammasome biology and developing targeted immune therapies.