| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IFNL2; IL-28A |
| Entrez GeneID | 282616 |
| clone | 7B9A4 |
| WB Predicted band size | 22.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL28A (AA: 1-200) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IL28A抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *"IL-28A (IFN-λ2) modulates immune responses in viral hepatitis through antibody-mediated receptor activation"*
**作者**: Smith A, et al.
**摘要**: 该研究探讨了IL28A抗体在慢性丙型肝炎中的作用，发现其通过激活IFN-λ受体通路增强抗病毒免疫反应，并可能影响干扰素疗法的治疗效果。
2. **文献名称**: *"Development of a monoclonal antibody specific to IL-28A for therapeutic targeting in autoimmune disorders"*
**作者**: Chen L, et al.
**摘要**: 研究团队开发了一种高特异性IL28A单克隆抗体，通过动物模型验证其抑制IL28A信号传导的能力，为类风湿性关节炎等自身免疫性疾病提供了潜在治疗策略。
3. **文献名称**: *"IL28A antibody-based detection in serum predicts hepatocellular carcinoma progression"*
**作者**: Tanaka K, et al.
**摘要**: 该文献建立了一种基于IL28A抗体的ELISA检测方法，用于定量分析肝癌患者血清中的IL28A水平，发现其表达与肿瘤侵袭性和预后显著相关。
备注：上述文献信息为示例性内容，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
The IL28A antibody is designed to detect interleukin-28A (IL-28A), a cytokine belonging to the type III interferon (IFN) family, also known as interferon lambda 2 (IFN-λ2). IL-28A is encoded by the *IL28A* gene and shares structural homology with IL-28B (IFN-λ3) and IL-29 (IFN-λ1). These cytokines bind to a heterodimeric receptor complex (IL-28R1/IL-10R2) to activate JAK-STAT signaling pathways, triggering antiviral and immunomodulatory responses. Unlike type I IFNs, type III IFNs primarily act on epithelial and mucosal surfaces, offering tissue-specific antiviral defense with reduced systemic inflammation.
IL28A antibodies are critical tools in research for detecting endogenous IL-28A expression in cells and tissues, enabling studies on its role in viral infections (e.g., hepatitis C, influenza, COVID-19), autoimmune disorders, and cancer. They are utilized in techniques like Western blotting, ELISA, and immunohistochemistry to quantify protein levels or visualize spatial distribution. Additionally, these antibodies aid in exploring IL-28A’s therapeutic potential, as recombinant IL-28A has shown promise in preclinical models for enhancing antiviral immunity or suppressing tumor growth. However, cross-reactivity with related IFN-λ isoforms requires careful validation to ensure specificity. Research on IL28A antibodies continues to advance understanding of type III IFN biology and their clinical applications.
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