| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IFNL2; IL-28A |
| Entrez GeneID | 282616 |
| clone | 6H9E6 |
| WB Predicted band size | 22.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL28A (AA: 1-200) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IL28A抗体的3篇参考文献的简要概括：
1. **文献名称**：*"Interleukin-28A polymorphisms correlate with antiviral response in chronic hepatitis C patients"*
**作者**：Tanaka Y, et al.
**摘要**：该研究探讨了IL28A基因多态性与丙型肝炎患者干扰素治疗应答的关系，利用IL28A抗体检测患者血清及组织中蛋白表达水平，发现特定基因型与抗病毒疗效显著相关。
2. **文献名称**：*"Differential expression of type III interferons in human immune cells revealed by IL28A-specific monoclonal antibodies"*
**作者**：Dellgren C, et al.
**摘要**：研究团队开发了针对IL28A的单克隆抗体，用于流式细胞术和免疫组化分析，发现IL28A在树突状细胞和巨噬细胞中高表达，提示其在先天免疫中的调控作用。
3. **文献名称**：*"IL28A antibody blockade suppresses viral replication in a murine model of hepatitis B infection"*
**作者**：Hong J, et al.
**摘要**：通过IL28A中和抗体在小鼠模型中抑制乙肝病毒复制，证实IL28A直接参与抗病毒信号通路，为靶向III型干扰素的治疗策略提供依据。
(注：上述文献为示例性概括，实际引用需以具体论文内容为准。)
The IL28A antibody targets interleukin-28A (IL-28A), also known as interferon lambda 2 (IFN-λ2), a cytokine belonging to the type III interferon family. Discovered in the early 2000s, IL-28A plays a critical role in antiviral immunity, particularly at mucosal surfaces. It signals through a heterodimeric receptor complex (IL-28Rα/IL-10Rβ), activating JAK-STAT pathways to induce interferon-stimulated genes (ISGs) that inhibit viral replication. Unlike type I interferons, IL-28A exhibits tissue-specific activity, primarily affecting epithelial cells and hepatocytes, which makes it a key player in infections like hepatitis C and respiratory viruses.
IL28A antibodies are essential tools for studying this cytokine’s expression, localization, and function. They enable detection via techniques like Western blot, ELISA, and immunohistochemistry, aiding research into IL-28A's role in viral defense, autoimmune disorders, and cancer. Clinically, IL-28A polymorphisms are linked to treatment outcomes in hepatitis C, influencing pegylated interferon/ribavirin therapy responses. Antibodies against IL-28A also hold therapeutic potential, either as neutralizing agents to modulate excessive inflammation or as agonists to boost antiviral activity. Their development underscores the growing interest in interferon lambda biology and its translational applications in infectious and inflammatory diseases.
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