Mouse Monoclonal CDH11 Antibody

The cadherin-11 (CDH11) antibody targets a transmembrane glycoprotein belonging to the cadherin superfamily, which mediates calcium-dependent cell-cell adhesion. CDH11 is primarily expressed in mesenchymal tissues, including osteoblasts, fibroblasts, and smooth muscle cells, playing critical roles in embryonic development, tissue morphogenesis, and wound healing. It regulates cellular processes such as migration, proliferation, and differentiation by interacting with intracellular catenins to link the actin cytoskeleton. Dysregulation of CDH11 has been implicated in pathological conditions, including cancer metastasis, fibrosis, and inflammatory diseases like rheumatoid arthritis. In cancer, CDH11 may promote tumor invasion and stromal interactions, while in fibrosis, it contributes to excessive extracellular matrix deposition. Antibodies against CDH11 are widely used in research to study its expression patterns, functional mechanisms, and therapeutic potential. They enable detection via techniques like immunohistochemistry, flow cytometry, and Western blot, aiding in biomarker discovery and target validation. Recent studies explore CDH11-blocking antibodies as therapeutic agents to inhibit pathological cell adhesion or signaling in autoimmune disorders and fibrotic diseases. Specificity and validation of CDH11 antibodies are essential, as cross-reactivity with other cadherins can affect experimental outcomes. Ongoing research continues to clarify its dual roles in tissue homeostasis and disease progression.