| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GH; GHN; GH-N; GHB5; hGH-N; IGHD1B |
| Entrez GeneID | 2688 |
| clone | 3H1C2 |
| WB Predicted band size | 24.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GH1 (AA: 1-217) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GH1抗体的3篇参考文献及其摘要概述：
1. **文献名称**: "Development of a sensitive ELISA for human growth hormone (GH1) using monoclonal antibodies"
**作者**: Smith A, et al.
**摘要**: 研究报道了一种基于单克隆GH1抗体的高灵敏度ELISA检测方法，用于定量血清中的人生长激素(GH1)，在儿童生长激素缺乏症的诊断中表现出高特异性。
2. **文献名称**: "Autoantibodies against GH1 in autoimmune hypophysitis: clinical implications"
**作者**: Garcia R, et al.
**摘要**: 探讨了自身免疫性垂体炎患者体内GH1抗体的存在及其与垂体功能减退的关系，提示此类抗体可能作为疾病活动的生物标志物。
3. **文献名称**: "Recombinant GH1 antibody fragments for targeted hormone delivery"
**作者**: Lee J, et al.
**摘要**: 描述了基因工程改造的GH1抗体片段(如scFv)用于靶向递送生长激素至特定组织，为激素替代治疗提供了新策略。
注：上述文献为示例，实际引用需根据具体研究内容检索PubMed、Web of Science等数据库获取。
The GH1 antibody is a specialized immunoglobulin designed to target and detect growth hormone 1 (GH1), a protein encoded by the *GH1* gene in humans. GH1. also known as pituitary growth hormone, is a 22 kDa polypeptide synthesized and secreted by somatotropic cells in the anterior pituitary gland. It plays a critical role in regulating growth, metabolism, and cellular repair through interactions with the growth hormone receptor (GHR), primarily in the liver and other tissues. Dysregulation of GH1 is linked to disorders such as growth hormone deficiency (GHD), gigantism, and acromegaly.
GH1 antibodies are widely utilized in research and diagnostics to quantify GH1 levels in serum, tissues, or cell cultures via techniques like ELISA, Western blotting, and immunohistochemistry. These antibodies are essential for studying GH1 expression patterns, secretion dynamics, and their correlation with pathological conditions. Monoclonal GH1 antibodies offer high specificity, recognizing a single epitope, while polyclonal variants detect multiple epitopes, enhancing sensitivity in diverse experimental setups.
Clinically, GH1 antibodies are employed to monitor recombinant growth hormone (rhGH) therapy in patients with GHD or Turner syndrome, ensuring appropriate dosing and assessing treatment efficacy. Additionally, they aid in differentiating pituitary adenoma subtypes. Recent advancements in antibody engineering have improved affinity and reduced cross-reactivity with structurally similar hormones like prolactin. Despite their utility, challenges remain in standardizing assays to account for GH1 isoforms and pulsatile secretion patterns. Overall, GH1 antibodies remain indispensable tools in both mechanistic studies and translational applications.
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