Mouse Monoclonal UL37 Antibody

The UL37 antibody targets the protein product of the UL37 gene, a conserved gene across herpesviruses, including human cytomegalovirus (HCMV) and herpes simplex virus (HSV). In HCMV, UL37 encodes multiple isoforms, notably pUL37x1. which plays critical roles in viral pathogenesis. It modulates mitochondrial dynamics, inhibits apoptosis, and facilitates viral egress by interacting with host trafficking proteins. In HSV-1. UL37 functions as a tegument protein involved in capsid transport and virion assembly. UL37 antibodies are essential tools for studying viral replication mechanisms, protein localization, and host-pathogen interactions. They enable detection of UL37 expression in infected cells via techniques like immunofluorescence, Western blotting, and immunoprecipitation. Research using UL37 antibodies has revealed its involvement in immune evasion, endoplasmic reticulum stress modulation, and mitochondrial fragmentation. These studies contribute to understanding herpesvirus persistence and potential therapeutic targets. Commercial UL37 antibodies are typically raised against recombinant protein fragments, with validation in specific virus-host systems. However, cross-reactivity between herpesvirus UL37 homologs may vary, necessitating careful validation for experimental applications.