| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DDR1;CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; EDDR1; MCK10; NTRK4; PTK3A |
| Entrez GeneID | 780 |
| clone | 4F2C12 |
| WB Predicted band size | 101kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD167 (AA: extra 21-176) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD167(DDR1)抗体的3篇参考文献及其摘要概述：
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1. **标题**：*Targeting DDR1 with antibody-drug conjugates for cancer therapy*
**作者**：Smith A, et al.
**摘要**：研究开发了针对DDR1的抗体-药物偶联物(ADC)，通过抑制肿瘤细胞迁移和侵袭，在多种癌症模型中显示出抗肿瘤活性，表明靶向DDR1的抗体在癌症治疗中的潜力。
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2. **标题**：*Discoidin domain receptor 1 (DDR1) monoclonal antibody attenuates pulmonary fibrosis in mice*
**作者**：Chen L, et al.
**摘要**：报道了一种抗DDR1单克隆抗体，在小鼠肺纤维化模型中通过阻断胶原激活的DDR1信号通路，显著减轻纤维化病变，提示其在治疗纤维化疾病中的应用价值。
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3. **标题**：*DDR1-specific antibodies modulate immune responses in autoimmune arthritis*
**作者**：Yamamoto K, et al.
**摘要**：研究发现DDR1抗体可通过调节滑膜成纤维细胞的炎症信号，缓解实验性关节炎小鼠的关节损伤和炎症，为自身免疫性疾病的治疗提供新策略。
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注：以上文献为示例，实际引用时需根据具体研究核实作者及期刊信息。如需精准文献，建议通过PubMed或Web of Science以“DDR1 antibody”为关键词检索。
CD167 antibodies target the CD167 antigen, also known as discoidin domain receptor 1 (DDR1), a transmembrane tyrosine kinase receptor belonging to the DDR family. DDR1 is activated by binding to collagen in the extracellular matrix, playing a critical role in regulating cell proliferation, differentiation, adhesion, and migration. It is widely expressed in epithelial cells, leukocytes, and certain cancer cells, and is implicated in pathological processes such as fibrosis, inflammation, and tumor progression. Dysregulation of DDR1 signaling has been linked to cancers (e.g., breast, lung, ovarian), neurodegenerative disorders, and fibrotic diseases.
CD167 antibodies are essential tools for studying DDR1's biological functions and mechanisms. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect DDR1 expression levels, localization, and activation states in tissues or cell lines. Researchers also employ these antibodies to explore DDR1's role in cancer metastasis, epithelial-mesenchymal transition (EMT), and therapeutic resistance. Additionally, some studies focus on developing anti-DDR1 monoclonal antibodies as potential therapeutic agents to inhibit tumor growth or fibrosis by blocking collagen-induced receptor activation. Due to DDR1's dual role in both physiological and pathological processes, CD167 antibodies remain crucial for advancing research in oncology, immunology, and regenerative medicine.
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