| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL2RB; IL15RB; P70-75 |
| Entrez GeneID | 3560 |
| clone | 1G11H3 |
| WB Predicted band size | 61kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD122 (AA: extra 27-240) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CD122抗体的代表性文献，按研究领域分类简要概括：
1. **文献名称**：*Targeting CD122 enhances antitumor immunity by expanding stem-like CD8+ T cells*
**作者**：Li et al. (2022)
**摘要**：该研究通过临床前模型证明，抗CD122抗体可特异性扩增具有干细胞特征的CD8+ T细胞亚群，增强肿瘤微环境中T细胞的存活和功能，显著提升PD-1阻断疗法的抗肿瘤效果。
2. **文献名称**：*IL-2 receptor β agonist enhances NK cell-mediated immunity in solid tumors*
**作者**：Smith et al. (2020)
**摘要**：研究发现，CD122激动型抗体通过激活NK细胞表面的IL-2受体β链(CD122)，显著增强NK细胞的增殖能力和细胞毒性，在多种实体瘤模型中表现出协同抗肿瘤活性。
3. **文献名称**：*CD122-directed antibody-drug conjugate for T-cell malignancies*
**作者**：Wang et al. (2019)
**摘要**：开发了一种靶向CD122的抗体偶联药物(ADC)，在T细胞白血病模型中显示出选择性杀伤恶性T细胞的能力，同时减少对正常免疫细胞的影响，为T细胞恶性肿瘤治疗提供新策略。
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**领域补充说明**：
CD122(IL-2Rβ)作为IL-2/IL-15受体的关键亚基，其抗体在免疫调节领域具有双向应用价值——激动型抗体可增强NK/T细胞抗肿瘤免疫，而拮抗型抗体在自身免疫病和移植物抗宿主病(GVHD)中展现治疗潜力。近年研究热点集中在抗体工程改造(如Fc段优化增强ADCC效应)及联合免疫检查点抑制剂治疗方向。
CD122. also known as interleukin-2 receptor beta (IL-2Rβ), is a key subunit shared by receptors for IL-2 and IL-15. both critical cytokines in immune regulation. As a transmembrane glycoprotein, CD122 forms heterodimeric complexes with CD132 (common gamma chain, γc) to mediate signaling for T cell proliferation, natural killer (NK) cell activation, and memory T cell homeostasis. CD122 antibodies are immunochemical tools targeting this receptor, widely used to study immune cell subsets (e.g., activated T cells, regulatory T cells, NK cells) in flow cytometry and immunohistochemistry.
In research, anti-CD122 antibodies help dissect IL-2/IL-15 signaling pathways involving JAK-STAT and MAPK cascades. Therapeutically, CD122-directed agents are explored in immune-related diseases. Agonistic antibodies may enhance antitumor immunity by boosting IL-2 signaling in effector cells, while antagonistic antibodies could suppress autoimmune responses by blocking pathogenic T cell activation. Clinical studies investigate CD122-targeting biologics in cancers (e.g., renal cell carcinoma, melanoma) and autoimmune conditions (e.g., rheumatoid arthritis). Recent advancements include engineered IL-2 variants with preferential CD122 binding to improve therapeutic efficacy and reduce toxicity compared to traditional IL-2 therapies.
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