Mouse Monoclonal KAT7 Antibody

The KAT7 (lysine acetyltransferase 7) antibody is a research tool used to study the function and expression of the KAT7 enzyme, a member of the MYST (MOZ, Ybf2/Sas3. Sas2. Tip60) family of histone acetyltransferases. KAT7. also known as HBO1 or MYST2. plays a critical role in epigenetic regulation by catalyzing the acetylation of histone H4. particularly at lysine 5. 8. and 12 residues, which is essential for chromatin remodeling, transcriptional activation, and DNA replication. It interacts with replication origin recognition complexes and regulates cell cycle progression, differentiation, and apoptosis. Dysregulation of KAT7 has been implicated in cancer, developmental disorders, and aging-related diseases. For instance, KAT7 overexpression is linked to tumorigenesis in certain cancers, while its inhibition shows potential in extending lifespan in preclinical models. The KAT7 antibody is widely employed in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry to investigate its localization, protein-protein interactions, and role in disease mechanisms. Recent studies also explore its therapeutic targeting in oncology. Validating antibody specificity via knockout/knockdown controls is crucial due to potential cross-reactivity with other MYST family members. This tool remains pivotal in advancing epigenetics and precision medicine research.