Mouse Monoclonal KMT5A Antibody

The KMT5A antibody is a crucial tool in epigenetic research, targeting the lysine methyltransferase 5A (KMT5A), also known as SET8 or PR-SET7. This enzyme catalyzes monomethylation of histone H4 at lysine 20 (H4K20me1), a modification linked to chromatin compaction, transcriptional regulation, and DNA damage repair. KMT5A plays dual roles in cellular processes: it supports genome stability during DNA replication and repair but may also promote tumor progression by silencing tumor suppressor genes. Researchers use KMT5A antibodies to study its expression, localization, and function in cell cycle control, cancer biology, and development. These antibodies are validated for techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Dysregulation of KMT5A is implicated in cancers, neurodegenerative diseases, and aging, making its study vital for understanding disease mechanisms. Commercial KMT5A antibodies are typically raised against specific epitopes, ensuring specificity for distinguishing monomethylation marks from related di-/trimethylated states. Recent studies also explore KMT5A's non-histone substrates, expanding its potential roles in cellular signaling. Reliable detection of KMT5A aids in uncovering its context-dependent functions and therapeutic targeting in precision medicine.