| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100 - 1/500 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MCH2 |
| Entrez GeneID | 839 |
| clone | 3B7E10 |
| WB Predicted band size | 33.3kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CASP6 (AA: 194–293) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CASP6抗体的3篇示例文献(内容基于典型研究主题构建，非真实文献，仅供参考)：
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1. **文献名称**：*Caspase-6 Activation in Alzheimer's Disease Neurons*
**作者**：Smith A.B., et al.
**摘要**：研究通过免疫印迹(Western blot)和免疫组化技术，使用特异性CASP6抗体验证其在阿尔茨海默病患者脑组织中的激活状态，发现CASP6活性升高与神经元凋亡及淀粉样斑块沉积相关。
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2. **文献名称**：*Role of Caspase-6 in Axonal Degeneration: Insights from a Mouse Model*
**作者**：Chen L., et al.
**摘要**：利用CASP6敲除小鼠及抗CASP6抗体进行免疫荧光染色，证明CASP6在轴突退行性变中的关键作用，并揭示其通过切割微管相关蛋白导致轴突结构破坏的机制。
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3. **文献名称**：*Development of a High-Specificity Monoclonal Antibody for Caspase-6 Detection in Human Cancers*
**作者**：Wang X., et al.
**摘要**：报道一种新型抗人CASP6单克隆抗体的开发与验证，通过ELISA和流式细胞术证实其高特异性，并应用于乳腺癌组织样本检测，发现CASP6表达与肿瘤侵袭性正相关。
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(注：如需真实文献，建议通过PubMed或Google Scholar检索关键词“Caspase-6 antibody”或“CASP6 detection”筛选近年研究。)
CASP6 (Caspase-6) is a member of the caspase family of cysteine-aspartic proteases, which play critical roles in apoptosis (programmed cell death), inflammation, and cellular differentiation. Specifically, CASP6 is an executioner caspase activated during apoptotic cascades, primarily by upstream initiator caspases like caspase-3 or caspase-8. Once activated, it cleaves substrates such as lamin A/C, nuclear mitotic apparatus protein, and actin, contributing to nuclear disassembly and cytoskeletal breakdown. CASP6 has also been implicated in neurodegenerative diseases, particularly Alzheimer’s disease, where its aberrant activation is linked to the cleavage of tau protein, leading to neurofibrillary tangle formation and neuronal dysfunction.
Antibodies targeting CASP6 are essential tools for studying its expression, localization, and activity in both physiological and pathological contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect CASP6 protein levels or cleavage-associated activation in tissues or cultured cells. Many CASP6 antibodies are raised against specific epitopes, such as the N-terminal prodomain or C-terminal regions, and their specificity is often validated using knockout cell lines or competitive peptide assays. Researchers also utilize CASP6 antibodies to explore its role in disease mechanisms, drug development, and biomarker discovery, particularly in neurodegeneration and cancer, where dysregulated apoptosis is a hallmark. Reliable CASP6 antibodies enable precise detection of both full-length and cleaved forms, aiding in the dissection of its dual roles in cell death and disease progression.
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