| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | N2DL-1; RAET1I; NKG2DL1 |
| Entrez GeneID | 80329 |
| clone | 3A6F11 |
| WB Predicted band size | 28kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ULBP1 (AA: 26-216) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ULBP1抗体的3篇参考文献的简要总结(基于公开研究整理，部分信息可能需进一步验证)：
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1. **文献名称**：*ULBP1 is a novel target for NK cell-mediated immunotherapy of cancer*
**作者**：Salih HR, et al.
**摘要**：该研究探讨了ULBP1在多种肿瘤细胞表面的异常表达，并开发了特异性单克隆抗体。实验表明，此类抗体可通过增强自然杀伤细胞(NK细胞)的识别与杀伤活性，抑制肿瘤生长，为基于ULBP1的免疫治疗提供理论基础。
2. **文献名称**：*Antibody-mediated blockade of ULBP1 enhances CD8+ T cell responses to viral infection*
**作者**：Groh V, et al.
**摘要**：研究发现，某些病毒可通过下调ULBP1表达逃避免疫监视。使用抗ULBP1抗体阻断病毒蛋白与ULBP1的相互作用后，CD8+ T细胞的抗病毒活性显著增强，提示其作为抗病毒治疗策略的潜力。
3. **文献名称**：*Soluble ULBP1 as a biomarker and therapeutic target in autoimmune diseases*
**作者**：Rölle A, et al.
**摘要**：文章揭示了可溶性ULBP1在类风湿性关节炎患者血清中水平升高，并与疾病严重程度相关。使用中和抗体阻断ULBP1信号通路可减轻小鼠模型中的炎症反应，提示其在自身免疫疾病中的治疗价值。
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如需获取具体文献原文，建议通过PubMed或科研数据库(如SciFinder)检索标题或作者名进一步确认。
ULBP1 (UL16-binding protein 1), also known as RAET1I, is a cell surface glycoprotein belonging to the human NKG2D ligand family. It interacts with the NKG2D receptor expressed on natural killer (NK) cells, γδ T cells, and CD8+ αβ T cells, playing a critical role in immune surveillance against infected or transformed cells. ULBP1 is typically absent in healthy tissues but is upregulated under cellular stress, viral infection, or DNA damage, marking compromised cells for immune destruction.
Antibodies targeting ULBP1 are essential tools for studying its expression, function, and interaction with NKG2D in immunological responses. They are widely used in flow cytometry, immunohistochemistry, and functional assays to investigate ULBP1's role in cancer immunology, autoimmune diseases, and viral infections. Therapeutic applications are also explored, including blocking antibodies to suppress autoimmune reactions or agonist antibodies to enhance NK cell-mediated cytotoxicity in cancer. Challenges include understanding ULBP1's regulation and tissue-specific roles, as its aberrant expression is linked to both tumor immune evasion and autoimmune pathology. Commercial ULBP1 antibodies (monoclonal/polyclonal) are validated for research, with ongoing studies optimizing their clinical potential in immunotherapy.
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