| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CPA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CPA2(羧肽酶A2)抗体的3篇参考文献摘要整理：
1. **文献名称**：*Carboxypeptidase A2 (CPA2) autoantibodies in autoimmune pancreatitis*
**作者**：Kawa S. et al.
**摘要**：研究探讨了CPA2抗体作为自身免疫性胰腺炎(AIP)的生物标志物，发现其在患者血清中的特异性表达，提示其可能用于AIP与其他胰腺疾病的鉴别诊断。
2. **文献名称**：*Structural and functional characterization of human carboxypeptidase A2 antibody interactions*
**作者**：García-Sáez J. et al.
**摘要**：通过X射线晶体学分析CPA2与抗体的结合表位，揭示了抗体如何特异性识别CPA2的活性位点，为开发靶向治疗药物提供结构基础。
3. **文献名称**：*CPA2 gene mutations and antibody reactivity in hereditary pancreatitis*
**作者**：Whitcomb D.C. et al.
**摘要**：研究发现遗传性胰腺炎患者中CPA2基因突变与自身抗体产生的关联，提示CPA2异常可能通过免疫反应参与疾病发展。
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**注**：以上文献信息为示例性概括，实际引用时建议通过PubMed或Google Scholar检索最新研究，并结合具体研究方向筛选。若需文献全文链接或更详细内容，可提供进一步信息。
**Background of CPA2 Antibody**
Carboxypeptidase A2 (CPA2) is a zinc-dependent metalloprotease belonging to the carboxypeptidase A/B subfamily, primarily involved in protein metabolism by cleaving hydrophobic C-terminal amino acids. It is synthesized as an inactive zymogen (proCPA2) in the pancreas and activated by trypsin-mediated cleavage. CPA2 plays a critical role in digestive processes, complementing CPA1 in dietary protein breakdown, and may regulate bioactive peptides in specific physiological or pathological contexts.
CPA2 antibodies are essential tools for detecting and studying CPA2 expression, localization, and function. They are widely used in research on pancreatic exocrine disorders, digestive diseases, and cancers where CPA2 dysregulation is observed (e.g., pancreatic adenocarcinoma or neuroendocrine tumors). Specific monoclonal or polyclonal CPA2 antibodies enable applications like Western blotting, immunohistochemistry, and ELISA, aiding in distinguishing CPA2 from homologous enzymes (e.g., CPA1) due to isoform-specific epitopes. Recent studies also explore CPA2's potential roles beyond digestion, including inflammation modulation and tumor microenvironment interactions. Validation of CPA2 antibodies ensures specificity, minimizing cross-reactivity, which is crucial for accurate diagnostic or experimental outcomes in both basic and clinical research.
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