| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HYPP; HOKPP; MiRP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KCNE3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与KCNE3抗体相关的代表性文献摘要(注：文献信息为模拟示例，实际引用请核实原始论文)：
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1. **文献名称**：*KCNE3 modulates the KCNQ1 potassium channel subunit in epithelia*
**作者**：Abbott GW et al.
**摘要**：本研究利用KCNE3特异性抗体，通过免疫共沉淀和免疫荧光技术，证实KCNE3蛋白与KCNQ1钾通道在结肠和肾脏上皮细胞中共定位。抗体阻断实验表明，KCNE3通过调节KCNQ1通道的门控特性，影响跨上皮氯离子分泌，为肠道液体平衡机制提供新见解。
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2. **文献名称**：*KCNE3 variants in Brugada syndrome: Functional characterization using antibody-based assays*
**作者**：Barajas-Martínez H et al.
**摘要**：通过Western blot和免疫组化结合KCNE3抗体，研究者发现Brugada综合征患者中KCNE3基因突变导致蛋白表达量下降。体外电生理实验进一步显示，突变体破坏KCNQ1-KCNE3通道复合物的功能，提示其与心律失常的病理关联。
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3. **文献名称**：*Antibody validation for KCNE3 in human cardiac tissue*
**作者**：Lundquist AL et al.
**摘要**：该研究系统验证了商用KCNE3抗体的特异性，通过siRNA敲低和过表达模型证明抗体识别目标蛋白的可靠性。应用该抗体发现KCNE3在人心室肌细胞中低表达，但在病理肥厚心肌组织中表达上调，提示其潜在的心脏重塑调控作用。
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4. **文献名称**：*KCNE3 deficiency alters intestinal ion transport in murine models*
**作者**：Preston P et al.
**摘要**：利用KCNE3敲除小鼠及抗体免疫染色，揭示KCNE3缺失导致结肠隐窝离子通道分布异常，引发腹泻表型。研究强调了KCNE3抗体在定位研究中的关键作用，为腹泻相关疾病的机制研究提供依据。
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建议通过PubMed或Web of Science以“KCNE3 antibody”为关键词检索最新文献，并优先选择高引用的方法学或疾病机制研究。
**Background of KCNE3 Antibody**
KCNE3. a member of the KCNE family of voltage-gated potassium (Kv) channel regulatory subunits, is a small transmembrane protein that modulates the function of potassium channels such as KCNQ1. It plays a critical role in regulating cardiac and muscle excitability, ion transport, and cellular electrical signaling. KCNE3 antibodies are immunological tools designed to detect and study the expression, localization, and functional interactions of KCNE3 in research and diagnostic contexts.
These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate KCNE3's involvement in physiological and pathological processes. For instance, KCNE3 dysfunction has been linked to cardiac arrhythmias, skeletal muscle disorders, and inherited conditions like hypokalemic periodic paralysis. Researchers employ KCNE3 antibodies to explore its regulatory mechanisms in Kv channel complexes, its tissue-specific distribution, and its role in disease pathogenesis.
Monoclonal and polyclonal KCNE3 antibodies are generated using immunogenic peptide sequences, often validated for specificity and cross-reactivity. Their applications extend to drug discovery, where they help assess therapeutic targeting of potassium channels. Overall, KCNE3 antibodies serve as essential reagents for advancing understanding of ion channel biology and related disorders.
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