Rabbit Polyclonal XPR1 Antibody

The XPR1 (Xenotropic and Polytropic Retrovirus Receptor 1) antibody is a tool used to study the XPR1 protein, a cell-surface transporter implicated in phosphate homeostasis. Originally identified as a receptor for xenotropic murine leukemia retroviruses (X-MLVs), XPR1 gained broader attention for its role in regulating inorganic phosphate (Pi) export from cells. This function links it to disorders involving phosphate dysregulation, such as neurodegenerative diseases and certain cancers. XPR1 antibodies are primarily employed in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies using these antibodies have revealed XPR1's presence in tissues like the liver, kidney, and brain, underscoring its systemic role in phosphate balance. Recent research also explores its potential as a therapeutic target, particularly in cancers where phosphate signaling contributes to proliferation. However, the exact molecular mechanisms of XPR1-mediated phosphate transport remain under investigation. Commercially available XPR1 antibodies vary in specificity, often requiring validation for experimental models. Overall, XPR1 antibodies serve as critical reagents for unraveling the protein's physiological and pathological roles in cellular metabolism and disease.