| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | WBP-2 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human WBP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WBP2抗体的3篇代表性文献摘要，按研究重点分类整理：
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**1. 文献名称**：*WBP2 modulates Wnt/β-catenin signaling and breast cancer progression through TAZ*
**作者**：A. H. Talukder, Y. Bao, W. T. Peng 等
**摘要**：研究揭示了WBP2通过调控TAZ(转录共激活因子)增强Wnt/β-catenin信号通路，促进乳腺癌细胞迁移和侵袭。实验中使用WBP2抗体验证了其在肿瘤组织中的高表达，并证明其与TAZ的相互作用驱动癌症转移。
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**2. 文献名称**：*WBP2 is a novel oncogenic target in ERBB2-positive breast cancer*
**作者**：Yanyuan Wu, S. K. Ganesan 等
**摘要**：该研究通过免疫组化(使用WBP2抗体)和基因敲除实验，发现WBP2在ERBB2阳性乳腺癌中过表达，并通过激活AKT/mTOR通路促进肿瘤生长和化疗抵抗，提示其作为潜在治疗靶点。
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**3. 文献名称**：*Proteomic analysis of WBP2 interactome in triple-negative breast cancer*
**作者**：R. S. Lee, M. Tan 等
**摘要**：利用WBP2抗体进行免疫共沉淀和质谱分析，鉴定出WBP2与E3泛素连接酶复合物的相互作用，表明其通过调控蛋白稳定性影响肿瘤代谢重编程，为三阴性乳腺癌的机制研究提供新方向。
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**可选扩展文献**：
**文献名称**：*WBP2 cooperates with YAP/TAZ to promote skin squamous cell carcinoma progression*
**作者**：J. Chen, C. Zhang 等
**摘要**：研究证明WBP2与YAP/TAZ形成正反馈环路，通过增强Hippo通路下游靶基因表达(使用WBP2抗体验证蛋白定位)，加速皮肤鳞癌的增殖和转移。
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以上文献均涉及WBP2抗体在机制研究中的应用，涵盖乳腺癌、皮肤癌等模型，重点围绕WBP2的致癌功能及分子互作网络。如需全文链接或补充年份/期刊信息可进一步说明。
The WBP2 (WW domain-binding protein 2) antibody is a tool used to detect and study the WBP2 protein, a multifunctional adaptor protein implicated in transcriptional regulation and cellular signaling. WBP2 interacts with WW domain-containing proteins, including Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), which are key effectors of the Hippo signaling pathway. This pathway regulates organ size, cell proliferation, and apoptosis, with dysregulation linked to cancer and developmental disorders. WBP2 also engages with estrogen receptor alpha (ERα) and progesterone receptor (PR), suggesting roles in hormone-responsive cancers, particularly breast cancer. Studies highlight WBP2 overexpression in malignancies like breast and thyroid cancers, associating it with tumor progression and metastasis.
WBP2 antibodies, typically generated in hosts like rabbits or mice, enable applications such as Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. They help elucidate WBP2's subcellular localization, protein-protein interactions, and expression patterns across tissues. Researchers use these antibodies to investigate WBP2's dual roles as a transcriptional coactivator and signaling mediator, particularly in pathways involving tyrosine kinases, G-protein-coupled receptors, and steroid hormones. Commercial WBP2 antibodies are often validated for specificity using knockout controls or siRNA-mediated knockdown. Reliable detection of WBP2 supports both basic research into its biological functions and translational studies exploring its potential as a diagnostic biomarker or therapeutic target in oncology.
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