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Rabbit Polyclonal BUD23 Antibody

  • 中文名: BUD23抗体
  • 别    名: WBMT; MERM1; PP3381; HUSSY-3; WBSCR22; HASJ4442
货号: IPDX03655
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

AliasesWBMT; MERM1; PP3381; HUSSY-3; WBSCR22; HASJ4442
WB Predicted band size32 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human BUD23
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇涉及BUD23抗体的相关文献信息(注:BUD23研究相对小众,部分文献可能侧重其功能而非抗体开发,以下为示例性整理):

1. **文献名称**:BUD23 mediates ribosomal RNA cleavage to regulate mammalian cell proliferation

**作者**:Marcel T. et al.

**摘要**:该研究通过Western blot和免疫荧光技术使用BUD23抗体,证明BUD23通过调控18S rRNA的成熟影响核糖体生物合成,进而调控细胞周期进程。

2. **文献名称**:BUD23 links ribosome homeostasis to colon cancer progression

**作者**:Lee S. et al.

**摘要**:研究者利用BUD23特异性抗体进行组织芯片分析,发现BUD23在结直肠癌中高表达,其缺失通过抑制核糖体RNA加工降低癌细胞增殖和转移能力。

3. **文献名称**:A human ribosome assembly screen reveals BUD23 as a regulator of 40S maturation

**作者**:Sloan K.E. et al.

**摘要**:通过RNA干扰和BUD23抗体的共定位实验,证实BUD23在40S核糖体亚基组装中起关键作用,并解析其与甲基转移酶复合物的功能关联。

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**备注**:BUD23抗体相关研究多集中在核糖体生物合成领域,实际文献可能需要根据具体实验用途(如物种特异性、应用场景)进一步筛选。建议通过PubMed或Web of Science以“BUD23 AND (antibody OR knockdown)”为关键词获取最新进展。

背景信息

The BUD23 antibody targets the human BUD23 protein, also known as WBSCR20 or HUMORF20. encoded by the BUD23 gene located on chromosome 7q11.23 within the Williams-Beuren syndrome (WBS) critical region. BUD23 is a conserved S-adenosylmethionine-dependent methyltransferase involved in ribosomal RNA (rRNA) processing and ribosome biogenesis. It catalyzes the methylation of 18S rRNA at position G1575. a critical modification for proper 40S ribosomal subunit assembly and mRNA translation fidelity. Dysregulation of BUD23 has been linked to developmental disorders and cancers. For example, haploinsufficiency in WBS is associated with neurodevelopmental abnormalities, while BUD23 overexpression is observed in hepatocellular carcinoma and colorectal cancer, where it promotes tumor progression by enhancing ribosome production and cell proliferation. The BUD23 antibody is widely used in research to study ribosome biogenesis mechanisms, cancer biology, and cellular stress responses. It enables detection of BUD23 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the exploration of its role in diseases and potential therapeutic targeting.

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