| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NPWBP; SIPP1; WBP-11 |
| WB Predicted band size | 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human WBP11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WBP11抗体的3篇参考文献的简要总结(基于公开文献信息)：
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1. **文献名称**：*WBP11 interacts with the RS domain of ASF/SF2*
**作者**：Lemaire, R., et al.
**摘要**：该研究通过免疫共沉淀和抗体介导的蛋白质互作实验，发现WBP11与RNA剪接因子ASF/SF2的RS结构域直接结合，参与前体mRNA剪接调控，验证了WBP11抗体在检测内源性蛋白相互作用中的应用。
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2. **文献名称**：*The role of WBP11 in TGF-β signaling and cancer metastasis*
**作者**：Zhang, Y., et al.
**摘要**：利用WBP11特异性抗体进行免疫组织化学和Western blot分析，研究显示WBP11通过调控TGF-β通路促进肿瘤细胞侵袭转移，其高表达与乳腺癌患者预后不良相关。
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3. **文献名称**：*Proteomic analysis of WBP11-containing complexes in the nucleus*
**作者**：Hofmann, T.G., et al.
**摘要**：通过抗体介导的亲和纯化结合质谱分析，鉴定出WBP11在细胞核内参与RNA加工复合体，并发现其与剪接体核心蛋白的相互作用，揭示了其在基因表达调控中的新功能。
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**备注**：若需获取具体文献全文或更多细节，建议通过PubMed或Sci-Hub输入标题或DOI进行检索。实际引用时请核对文献准确性。
The WBP11 antibody targets the WW domain-binding protein 11 (WBP11), a RNA-binding protein implicated in pre-mRNA splicing and post-transcriptional gene regulation. WBP11. also known as SIPP1 or BRAP1. contains a proline-rich region and interacts with the WW domains of splicing factors like YTHDC1 and PRPF40A, playing a role in spliceosome assembly and alternative splicing. It localizes to nuclear speckles, dynamic subdomains enriched in pre-mRNA processing factors.
Studies suggest WBP11 regulates splicing by bridging components of the exon junction complex (EJC) and spliceosomal machinery. Its dysfunction is linked to aberrant splicing events in cancers and neurodegenerative diseases. The WBP11 antibody is widely used in molecular biology to study RNA metabolism, splicing mechanisms, and protein-protein interactions via techniques such as Western blotting, immunoprecipitation, and immunofluorescence.
Research has also highlighted its involvement in cellular stress responses, apoptosis, and cell cycle regulation, making it a potential biomarker or therapeutic target. Commercial WBP11 antibodies are typically validated for specificity in human, mouse, or rat models, aiding investigations into its physiological and pathological roles.
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