WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
WB Predicted band size | 122 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide of human WDR6 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WDR6抗体的3篇文献示例(注:以下内容为模拟生成,实际文献需通过学术数据库查询确认):
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1. **"A monoclonal antibody against WDR6 reveals its role in ciliogenesis and neurodevelopmental disorders"**
*Authors: Chen, L., et al.*
**摘要**:本研究开发了一种特异性识别WDR6的单克隆抗体,通过免疫荧光和Western blot验证其在多种细胞模型中的有效性。研究发现WDR6与初级纤毛形成相关,其表达异常可能导致神经发育障碍。
2. **"WDR6 interacts with the histone methyltransferase complex: Evidence from co-immunoprecipitation using a novel polyclonal antibody"**
*Authors: Gupta, R., & Wang, Y.*
**摘要**:文章报道了一种新型多克隆抗体的制备,用于研究WDR6在表观遗传调控中的作用。通过免疫共沉淀实验,证实WDR6与组蛋白甲基转移酶复合物相互作用,可能参与基因沉默通路。
3. **"Validation of commercial WDR6 antibodies for immunohistochemical analysis in breast cancer tissues"**
*Authors: Kim, S., et al.*
**摘要**:系统评估了市售WDR6抗体的可靠性,发现部分抗体在乳腺癌组织切片中表现出高特异性和低背景信号。研究提示WDR6的高表达与乳腺癌患者预后不良相关。
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**提示**:如需真实文献,建议通过PubMed、Google Scholar等平台搜索关键词“WDR6 antibody”或“WDR6 immunohistochemistry”,筛选涉及抗体开发、验证或功能研究的论文。
The WDR6 (WD repeat domain 6) protein is a member of the WD-repeat protein family, characterized by conserved repeats of ~40 amino acids typically forming β-propeller structures that mediate protein-protein interactions. WDR6 is implicated in diverse cellular processes, including transcriptional regulation, ribosome biogenesis, and epigenetic modifications. It interacts with multiple molecular partners, such as histone methyltransferases and chromatin remodelers, suggesting roles in chromatin organization and gene expression control. Research links WDR6 to developmental pathways and cellular differentiation, with potential involvement in cell cycle progression and apoptosis.
Antibodies targeting WDR6 are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Such antibodies have been used to explore WDR6's association with diseases, including cancer (e.g., glioblastoma, hepatocellular carcinoma) and neurological disorders, where dysregulation of WDR6-related pathways may contribute to pathogenesis. Validation of WDR6 antibodies often includes knockout cell line controls to confirm specificity. Ongoing research aims to clarify WDR6's mechanistic roles and its potential as a therapeutic target, driving demand for reliable antibodies in both basic and translational studies.
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