Rabbit Polyclonal MAP3K20 Antibody

The MAP3K20 antibody is a research tool designed to detect and analyze the mitogen-activated protein kinase kinase kinase 20 (MAP3K20), a serine/threonine-protein kinase belonging to the MAP3K family. MAP3K20. also known as MLK4 or ZAK, plays a role in regulating cellular signaling pathways, particularly those involved in stress responses, apoptosis, and immune regulation. It functions upstream of MAPK pathways, including JNK and p38 MAPK cascades, influencing processes like cell proliferation, differentiation, and inflammation. The antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to study endogenous MAP3K20 expression, localization, and activation under physiological or pathological conditions. Research interest in MAP3K20 stems from its dual kinase domains and potential involvement in diseases such as cancer, neurodegenerative disorders, and fibrosis. For instance, aberrant MAP3K20 signaling has been linked to tumorigenesis and chemotherapy resistance. Validation of the antibody typically involves knockout or knockdown controls to confirm specificity. Its application aids in elucidating MAP3K20's interaction networks, post-translational modifications, and therapeutic targeting. However, challenges remain in understanding its tissue-specific roles due to overlapping functions with other MAP3K members.