| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HIP3; HYPH; HIP14; HSPC294 |
| WB Predicted band size | 73 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ZDHHC17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZDHHC17抗体的3篇参考文献示例(文献信息为虚构模拟，仅供参考)：
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1. **文献名称**: *ZDHHC17-mediated palmitoylation regulates dendritic spine formation in neurons*
**作者**: Chen L, et al.
**摘要**: 本研究利用特异性ZDHHC17抗体，通过免疫荧光和Western blot技术，发现ZDHHC17在小鼠海马神经元中通过棕榈酰化修饰突触蛋白PSD-95.调控树突棘形态发生，提示其在神经发育中的作用。
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2. **文献名称**: *Role of ZDHHC17 in cancer progression: Antibody-based detection in tumor tissues*
**作者**: Wang Y, et al.
**摘要**: 通过开发高特异性ZDHHC17单克隆抗体，研究者证实该蛋白在乳腺癌组织中的异常高表达，并与患者预后不良相关。抗体应用于免疫组化分析，为ZDHHC17作为肿瘤标志物提供了实验依据。
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3. **文献名称**: *ZDHHC17 interacts with Huntingtin and modulates its subcellular localization*
**作者**: Smith J, et al.
**摘要**: 使用ZDHHC17多克隆抗体进行免疫共沉淀实验，发现ZDHHC17与亨廷顿蛋白(Huntingtin)相互作用，调控其棕榈酰化及核质转运，提示其在亨廷顿舞蹈症病理机制中的潜在作用。
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注：以上文献为示例，实际研究中建议通过PubMed或Google Scholar以关键词“ZDHHC17 antibody”或“ZDHHC17 AND (Western blot/immunohistochemistry)”检索最新文献。
The ZDHHC17 antibody is a research tool designed to detect ZDHHC17. a member of the DHHC (Asp-His-His-Cys) family of palmitoyltransferases. These enzymes catalyze protein S-palmitoylation, a post-translational modification critical for regulating protein localization, stability, and function. ZDHHC17. also known as Huntingtin-interacting protein 14 (HIP14), is primarily expressed in the brain and plays a role in neuronal development, synaptic plasticity, and vesicle trafficking. It interacts with huntingtin, the protein mutated in Huntington’s disease, suggesting its involvement in neurodegenerative pathways.
Antibodies against ZDHHC17 are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, subcellular distribution, and interactions. Researchers employ these antibodies to explore ZDHHC17’s regulatory mechanisms in health and disease, particularly in neurological disorders and cancers. For instance, studies link ZDHHC17 dysregulation to Alzheimer’s disease, synaptic dysfunction, and tumor progression, highlighting its potential as a therapeutic target.
Commercial ZDHHC17 antibodies are typically validated for specificity using knockout cell lines or tissues to minimize cross-reactivity with other DHHC family members. However, variability in antibody performance across experimental conditions necessitates careful optimization. Recent research utilizing these antibodies has uncovered novel substrates of ZDHHC17 and clarified its role in lipid raft organization and signal transduction, advancing understanding of palmitoylation’s broader biological impact.
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